ReviewMammalian genome : official journal of the International Mammalian Genome Society2006
Epigenetics and phenotypic variation in mammals.
Review in Mammalian genome : official journal of the International Mammalian Genome Society, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed.
- Epigenomics and Ayurgenomics: Molecular Analysis of Ayurvedic Prakriti in Personalized Healthcare.Cureus · 2026Review
- Environmental Factors and Co-Occurrence Patterns Influence Dorsal Brightness in Two Jumping Mice Species in the Western United States.Ecology and evolution · 2026Article
- Article
- Role of intraflagellar transport protein IFT140 in the formation and function of motile cilia in mammals.Cellular and molecular life sciences : CMLS · 2025Article
- 3D Hepatocyte Model with Composite Nanofibers That Reproduced Human In Vivo Drug Clearance Profiles.ACS pharmacology & translational science · 2025Article
- Circulating microRNAs as Potential Biomarkers of Overweight and Obesity in Adults: A Narrative Review.Genes · 2025Review
- Unifying fragmented perspectives with additive deep learning for high-dimensional models from partial faceted datasets.npj biological physics and mechanics · 2025Article
- Epigenetic regulation in lung cancer.MedComm · 2023Review
- A permutation-based approach using a rank-based statistic to identify sex differences in epigenetics.Scientific reports · 2023Review
- Developmental origins of diabetes mellitus: Environmental epigenomics and emerging patterns.Journal of diabetes · 2023Review
- Environmental Adaptation of Genetically Uniform Organisms with the Help of Epigenetic Mechanisms-An Insightful Perspective on Ecoepigenetics.Epigenomes · 2022Review
- Implication of the Mediterranean diet on the human epigenome.Journal of preventive medicine and hygiene · 2022Review
- Integrative Genome-Wide DNA Methylome and Transcriptome Analysis of Ovaries from Hu Sheep with High and Low Prolific.Frontiers in cell and developmental biology · 2022Article
- Chronic Lithium Treatment Affects Anxious Behaviors and theExpression of Serotonergic Genes in Midbrain Raphe Nuclei of Defeated Male Mice.Biomedicines · 2021Article
- Histone Methylation Regulation in Neurodegenerative Disorders.International journal of molecular sciences · 2021Review
- The Role of Cell Tracing and Fate Mapping Experiments in Cardiac Outflow Tract Development, New Opportunities through Emerging Technologies.Journal of cardiovascular development and disease · 2021Review
- Epigenetic variation in animal populations: Sources, extent, phenotypic implications, and ecological and evolutionary relevance.Journal of biosciences · 2021Review
- Impact of Genetic Variations and Epigenetic Mechanisms on the Risk of Obesity.International journal of molecular sciences · 2020Review
- DuplicatedGenes · 2020Article
- Sources of epigenetic variation and their applications in natural populations.Evolutionary applications · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
What causes phenotypic variation? By now it is clear that phenotype is a result of the interaction between genotype and environment, in addition to variation not readily attributable to either. Epigenetic phenomena associated with phenotypic variation at the biochemical, cellular, tissue, and organism level are now well recognized and are likely to contribute to the "intangible variation" alluded to. While it is clear that epigenetic modifications are mitotically heritable, the fidelity of this process is not well understood. Inheritance through more than one generation of meioses is even less well studied. So it remains unclear to what extent epigenetic changes contribute to phenotypic variation in natural populations. How might such evidence be obtained? What are the features of phenotypes that might suggest an epigenetic component? How much of the epigenetic component is truly independent of genetic changes? The answers to such questions must come from studies designed specifically to detect subtle, stochastically determined phenotypic variation in suitable animal models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.