ArticleDie Naturwissenschaften2006
Isolation and characterization of melanopsin and pinopsin expression within photoreceptive sites of reptiles.
Article in Die Naturwissenschaften, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 53 citations in OpenAlex.
- Pinopsin Regulates Melatonin Production and Daily Locomotor Activity: Functional Insights From Gene-Edited Xenopus Tadpoles.Journal of pineal research · 2026Article
- Evolution of Pineal Nonvisual Opsins in Lizards and the Tuatara and Identification of Lepidopsin: A New Opsin Gene.Genome biology and evolution · 2025Article
- Functional diversification process of opsin genes for teleost visual and pineal photoreceptions.Cellular and molecular life sciences : CMLS · 2024Article
- Melanopsin-mediated optical entrainment regulates circadian rhythms in vertebrates.Communications biology · 2023Review
- Deep Diversity: Extensive Variation in the Components of Complex Visual Systems across Animals.Cells · 2022Review
- Characterization of the melanopsin gene (Opn4x) of diurnal and nocturnal snakes.BMC evolutionary biology · 2019Article
- Evolutionary history of teleost intron-containing and intron-less rhodopsin genes.Scientific reports · 2019Article
- Pinopsin evolved as the ancestral dim-light visual opsin in vertebrates.Communications biology · 2018Article
- Dexamethasone Modulates Nonvisual Opsins, Glucocorticoid Receptor, and Clock Genes inBioMed research international · 2017Article
- Diversification of non-visual photopigment parapinopsin in spectral sensitivity for diverse pineal functions.BMC biology · 2015Article
- Imidacloprid induces morphological and molecular damages on testis of lizard (Podarcis sicula).Ecotoxicology (London, England) · 2015Article
- Shedding new light on opsin evolution.Proceedings. Biological sciences · 2012Review
- Article
- Intrinsically photosensitive retinal ganglion cells.Physiological reviews · 2010Review
- Melanopsin and inner retinal photoreception.Cellular and molecular life sciences : CMLS · 2010Review
- The evolution of irradiance detection: melanopsin and the non-visual opsins.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Review
- Clockwork blue: on the evolution of non-image-forming retinal photoreceptors in marine and terrestrial vertebrates.Die Naturwissenschaften · 2008Review
- Evolution of melanopsin photoreceptors: discovery and characterization of a new melanopsin in nonmammalian vertebrates.PLoS biology · 2006Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-mammalian vertebrates have multiple extraocular photoreceptors, mainly localised in the pineal complex and the brain, to mediate irradiance detection. In this study, we report the full-length cDNA cloning of ruin lizard melanopsin and pinopsin. The high level of identity with opsins in both the transmembrane regions, where the chromophore binding site is located, and the intracellular loops, where the G-proteins interact, suggests that both melanopsin and pinopsin should be able to generate a stable photopigment, capable of triggering a transduction cascade mediated by G-proteins. Phylogenetic analysis showed that both opsins are located on the expected branches of the corresponding sequences of ortholog proteins. Subsequently, using RT-PCR and RPA analysis, we verified the expression of ruin lizard melanopsin and pinopsin in directly photosensitive organs, such as the lateral eye, brain, pineal gland and parietal eye. Melanopsin expression was detected in the lateral eye and all major regions of the brain. However, different from the situation in Xenopus and chicken, melanopsin is not expressed in the ruin lizard pineal. Pinopsin mRNA expression was only detected in the pineal complex. As a result of their phylogenetic position and ecology, reptiles provide the circadian field with some of the most interesting models for understanding the evolution of the vertebrate circadian timing system and its response to light. This characterization of melanopsin and pinopsin expression in the ruin lizard will be important for future studies aimed at understanding the molecular basis of circadian light detection in reptiles.
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