Trial reportJournal of perinatology : official journal of the California Perinatal Association2006
Work of breathing using high-flow nasal cannula in preterm infants.
Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 45 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Humidified High Flow Nasal Cannula to Nasal Continuous Positive Airway Pressure for Non-Invasive Respiratory Support in Neonates
Choice and Optimal Settings of Non Invasive Respiratory Support in Preterm Newborns < 30 Gestational Weeks
Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 208 citations in OpenAlex.
- High flow nasal cannula for respiratory support in term infants.The Cochrane database of systematic reviews · 2023Pooled it
- High flow nasal cannula for respiratory support in preterm infants.The Cochrane database of systematic reviews · 2016Pooled it
- Physiological effects of high-flow nasal cannula therapy in preterm infants.Archives of disease in childhood. Fetal and neonatal edition · 2020Trial
- Diaphragm electromyography results at different high flow nasal cannula flow rates.European journal of pediatrics · 2019Trial
- High-flow nasal cannula and extubation success in the premature infant: a comparison of two modalities.Journal of perinatology : official journal of the California Perinatal Association · 2010Trial
- Article
- High-flow nasal cannula is an expensive and clunky placebo: myth or maxim?Breathe (Sheffield, England) · 2024Review
- The effects of flow settings during high-flow nasal cannula oxygen therapy for neonates and young children.European respiratory review : an official journal of the European Respiratory Society · 2024Review
- Nasal high flow therapy for primary respiratory support in preterm infants.The Cochrane database of systematic reviews · 2023Review
- Clinical review of high-flow nasal oxygen therapy in human and veterinary patients.Frontiers in veterinary science · 2023Review
- Heated Humidified High-Flow Nasal Cannula in Children: State of the Art.Biomedicines · 2022Review
- High-Flow Nasal Oxygenation and Its Applicability in COVID Patients.SN comprehensive clinical medicine · 2022Review
- High-Flow Nasal Cannula Oxygen Therapy: Physiological Mechanisms and Clinical Applications in Children.Frontiers in medicine · 2022Review
- Transcutaneous monitoring of diaphragm activity as a measure of work of breathing in preterm infants.Pediatric pulmonology · 2021Article
- Clinical practices related to high-flow nasal cannulas in pediatric critical care in Brazil compared to other countries: a Brazilian survey.Revista Brasileira de terapia intensiva · 2021Article
- Mechanisms of nasal high flow therapy in newborns.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- The Comparison of HHHFNC and NCPAP in Extremely Low-Birth-Weight Preterm Infants After Extubation: A Single-Center Randomized Controlled Trial.Frontiers in pediatrics · 2020Article
- Predicting Lung Health Trajectories for Survivors of Preterm Birth.Frontiers in pediatrics · 2020Review
- Heated and Humidified High Flow Nasal Canal Oxygen Supplementation as an Effective Treatment for High-Risk Prethreshold Retinopathy of Prematurity.Translational vision science & technology · 2019Article
- Nasal high flow: physiology, efficacy and safety in the acute care setting, a narrative review.Open access emergency medicine : OAEM · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare the work of breathing (WOB) in premature neonates supported with high-flow nasal cannula (HFNC) and nasal continuous positive airway pressure (NCPAP). STUDY
designEighteen preterm neonates <2.0 kg on HFNC or NCPAP support were studied in a random order. A ventilator was used to deliver 6 cm H2O of NCPAP with nasal prongs. High-flow nasal cannula delivered with Vapotherm (VAPO) at 3, 4 and 5 l/min was used. Tidal ventilation was obtained using respiratory inductance plethysmography calibrated with face-mask pneumotachography. An esophageal balloon estimated pleural pressure from which changes in end distending pressure were calculated. Inspiratory, elastic and resistive WOB and respiratory parameters were calculated.
resultsNo differences were found in the WOB for all settings. Changes in end distending pressure did not vary significantly over all device settings except VAPO at 5 l/min.
conclusionIn these preterm infants with mild respiratory illness, HFNC provided support comparable to NCPAP.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.