ArticleGenome research2006
An epigenetic state associated with areas of gene duplication.
Article in Genome research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Genome-wide stability of the DNA replication program in single mammalian cells.Nature genetics · 2019Article
- Copy number variation in the horse genome.PLoS genetics · 2014Article
- Article
- Strain-specific copy number variation in the intelectin locus on the 129 mouse chromosome 1.BMC genomics · 2011Article
- Achieving singularity in mammalian odorant receptor gene choice.Chemical senses · 2010Review
- Global organization of replication time zones of the mouse genome.Genome research · 2008Article
- Evolution and control of imprinted FWA genes in the genus Arabidopsis.PLoS genetics · 2008Article
- Segmental duplications and evolutionary plasticity at tumor chromosome break-prone regions.Genome research · 2008Article
- Monoallelic expression of multiple genes in the CNS.PloS one · 2007Article
- Differences between homologous alleles of olfactory receptor genes require the Polycomb Group protein Eed.The Journal of cell biology · 2007Article
- Gene cluster lock after pheromone receptor gene choice.The EMBO journal · 2007Article
- Replication profile of PCDH11X and PCDH11Y, a gene pair located in the non-pseudoautosomal homologous region Xq21.3/Yp11.2.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2007Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Asynchronous DNA replication is an epigenetically determined feature found in all cases of monoallelic expression, including genomic imprinting, X-inactivation, and random monoallelic expression of autosomal genes such as immunoglobulins and olfactory receptor genes. Most genes of the latter class were identified in experiments focused on genes functioning in the chemosensory and immune systems. We performed an unbiased survey of asynchronous replication in the mouse genome, excluding known asynchronously replicated genes. Fully 10% (eight of 80) of the genes tested exhibited asynchronous replication. A common feature of the newly identified asynchronously replicated areas is their proximity to areas of tandem gene duplication. Testing of other clustered areas supported the idea that such regions are enriched with asynchronously replicated genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.