ArticleMolecular biology of the cell2006
The docking protein Cas links tyrosine phosphorylation signaling to elongation of cerebellar granule cell axons.
Article in Molecular biology of the cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Upregulation of Neural Cell Adhesion Molecule 1 and Excessive Migration of Purkinje Cells in Cerebellar Cortex.Frontiers in neuroscience · 2021Article
- Temporal analysis of hippocampal CA3 gene coexpression networks in a rat model of febrile seizures.Disease models & mechanisms · 2018Article
- Cas adaptor proteins organize the retinal ganglion cell layer downstream of integrin signaling.Neuron · 2014Article
- Oligodendroglial p130Cas is a target of Fyn kinase involved in process formation, cell migration and survival.PloS one · 2014Article
- Profiling, Bioinformatic, and Functional Data on the Developing Olfactory/GnRH System Reveal Cellular and Molecular Pathways Essential for This Process and Potentially Relevant for the Kallmann Syndrome.Frontiers in endocrinology · 2013Article
- Ethanol disrupts axon outgrowth stimulated by netrin-1, GDNF, and L1 by blocking their convergent activation of Src family kinase signaling.Journal of neurochemistry · 2012Article
- Netrin-1 attracts axons through FAK-dependent mechanotransduction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Systematizing and cloning of genes involved in the cerebellar cortex circuit development.Neurochemical research · 2011Review
- Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction.The Journal of biological chemistry · 2011Article
- The SH2 domain protein Shep1 regulates the in vivo signaling function of the scaffolding protein Cas.Cellular signalling · 2010Article
- The SRC homology 2 domain protein Shep1 plays an important role in the penetration of olfactory sensory axons into the forebrain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Developmentally regulated Ca2+-dependent activator protein for secretion 2 (CAPS2) is involved in BDNF secretion and is associated with autism susceptibility.Cerebellum (London, England) · 2009Review
- Ethanol inhibits neuronal differentiation by disrupting activity-dependent neuroprotective protein signaling.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Opalin, a transmembrane sialylglycoprotein located in the central nervous system myelin paranodal loop membrane.The Journal of biological chemistry · 2008Article
- Very-KIND, a KIND domain containing RasGEF, controls dendrite growth by linking Ras small GTPases and MAP2.The Journal of cell biology · 2007Article
- Developmental expression and differentiation-related neuron-specific splicing of metastasis suppressor 1 (Mtss1) in normal and transformed cerebellar cells.BMC developmental biology · 2007Article
- The EphA4 receptor regulates dendritic spine remodeling by affecting beta1-integrin signaling pathways.The Journal of cell biology · 2007Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Crk-associated substrate (Cas) is a tyrosine-phosphorylated docking protein that is indispensable for the regulation of the actin cytoskeletal organization and cell migration in fibroblasts. The function of Cas in neurons, however, is poorly understood. Here we report that Cas is dominantly enriched in the brain, especially the cerebellum, of postnatal mice. During cerebellar development, Cas is highly tyrosine phosphorylated and is concentrated in the neurites and growth cones of granule cells. Cas coimmunoprecipitates with Src family protein tyrosine kinases, Crk, and cell adhesion molecules and colocalizes with these proteins in granule cells. The axon extension of granule cells is inhibited by either RNA interference knockdown of Cas or overexpression of the Cas mutant lacking the YDxP motifs, which are tyrosine phosphorylated and thereby interact with Crk. These findings demonstrate that Cas acts as a key scaffold that links the proteins associated with tyrosine phosphorylation signaling pathways to the granule cell axon elongation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.