ArticleAJNR. American journal of neuroradiology2006
Temporal lobe involvement in Japanese encephalitis: problems in differential diagnosis.
Article in AJNR. American journal of neuroradiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 74 citations in OpenAlex.
- Beyond the borders-coma as a complication of imported Japanese encephalitis: a case report.Journal of medical case reports · 2026Article
- Japanese Encephalitis: Characteristic Imaging in Substantia Nigra, Thalamus, and Basal Ganglia.Internal medicine (Tokyo, Japan) · 2026Article
- Mice as an Animal Model for Japanese Encephalitis Virus Research: Mouse Susceptibility, Infection Route, and Viral Pathogenesis.Pathogens (Basel, Switzerland) · 2023Review
- Detection of Japanese Encephalitis by Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid: A Case Report and Literature Review.Frontiers in cellular neuroscience · 2022Article
- Adults with severe Japanese encephalitis: a retrospective analysis of 9 cases in Linyi, China.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- MRI Spectrum of Japanese Encephalitis in Northeast India: A Cross-Sectional Study.Journal of neurosciences in rural practice · 2021Article
- Understanding and managing acute encephalitis.F1000Research · 2020Review
- Infectious Temporal Lobe Encephalitis-Not Just Herpes!The Neurohospitalist · 2018Article
- Japanese Encephalitis Virus Infection Results in Transient Dysfunction of Memory Learning and Cholinesterase Inhibition.Molecular neurobiology · 2017Article
- Clinical Characteristics of Severe Japanese Encephalitis: A Case Series from South Korea.The American journal of tropical medicine and hygiene · 2017Article
- Imaging in viral infections of the central nervous system: can images speak for an acutely ill brain?Emergency radiology · 2017Review
- Viral encephalitis in travellers.Clinical medicine (London, England) · 2015Article
- Clinical and radiological predictors of outcome for Murray Valley encephalitis.The American journal of tropical medicine and hygiene · 2013Article
- Neuro-intensive care of patients with acute CNS infections.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2012Review
- An evaluation of the usefulness of neuroimaging for the diagnosis of Japanese encephalitis.Journal of neurology · 2009Article
- Coinfection of Japanese encephalitis with neurocysticercosis: an imaging study.AJNR. American journal of neuroradiology · 2008Article
- Fever of unknown origin due to zoonoses.Infectious disease clinics of North America · 2007Review
- ASL perfusion in atypical Japanese encephalitis.The Indian journal of radiology & imagingArticle
- Changing Spectrum of Acute Encephalitis Syndrome in India and a Syndromic Approach.Annals of Indian Academy of NeurologyArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeOn MR imaging and CT, Japanese encephalitis (JE) shows lesions in the thalami, substantia nigra, basal ganglia, cerebral cortex, cerebellum, brain stem, and white matter, whereas temporal lobe involvement is characteristically seen in Herpes simplex encephalitis (HSE). Temporal lobe involvement in JE may cause problems in differentiating it from HSE. We undertook this study to show the temporal lobe involvement pattern in JE and highlight differentiating features from temporal lobe involvement in HSE.
methodsSixty-two patients with JE underwent CT or MR imaging or both. MR imaging was done in 53 and CT in 53. The diagnosis of JE was confirmed by cerebrospinal fluid (CSF) IgM enzyme-linked immunosorbent assay.
resultsEleven (17.7%) patients showed temporal lobe involvement with abnormal MR imaging in all. All the patients showed hippocampal involvement. Two patients showed extension of lesions into the amygdala and uncus with insular involvement in 1. The rest of the temporal lobe was spared. All patients had thalamic and substantia nigra involvement with basal ganglia involvement in 7. Six of 9 CT scans were abnormal and the temporal lesions were seen in 2.
conclusionsThe temporal lobe involvement pattern is fairly characteristic and mostly involves the hippocampus, usually sparing the rest of the temporal lobe. This and the concurrent involvement of the thalami, substantia nigra (SN), and basal ganglia allow differentiation from HSE. However, if the temporal lobe involvement is more severe, laboratory tests may be the only way to differentiate it from HSE, and it may be prudent to start antiviral therapy in the interim period.
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16687537PMC7975744W1816772987What OpenQuestion holds
Registered trials
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