ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Two mRNA-binding proteins regulate the distribution of syntaxin mRNA in Aplysia sensory neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Role of CPEBs in Learning and Memory.Journal of neurochemistry · 2025Review
- An Interaction Network of RNA-Binding Proteins Involved inMolecular & cellular proteomics : MCP · 2020Article
- Cataloguing and Selection of mRNAs Localized to Dendrites in Neurons and Regulated by RNA-Binding Proteins in RNA Granules.Biomolecules · 2020Review
- The crystal structure of Staufen1 in complex with a physiological RNA sheds light on substrate selectivity.Life science alliance · 2018Article
- Comprehensive Evolutionary Analysis of the Major RNA-Induced Silencing Complex Members.Scientific reports · 2018Article
- Article
- The multifunctional Staufen proteins: conserved roles from neurogenesis to synaptic plasticity.Trends in neurosciences · 2014Review
- Regulation of mRNA transport, localization and translation in the nervous system of mammals (Review).International journal of molecular medicine · 2014Review
- AU-rich element-binding protein negatively regulates CCAAT enhancer-binding protein mRNA stability during long-term synaptic plasticity in Aplysia.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Relationship of axonal voltage-gated sodium channel 1.8 (NaV1.8) mRNA accumulation to sciatic nerve injury-induced painful neuropathy in rats.The Journal of biological chemistry · 2011Article
- mRNA binding protein staufen 1-dependent regulation of pyramidal cell spine morphology via NMDA receptor-mediated synaptic plasticity.Molecular brain · 2011Article
- Mechanisms of translational regulation in synaptic plasticity.Current opinion in neurobiology · 2010Review
- Multimerization of Staufen1 in live cells.RNA (New York, N.Y.) · 2010Article
- Review
- C. elegans and H. sapiens mRNAs with edited 3' UTRs are present on polysomes.RNA (New York, N.Y.) · 2008Article
- Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Targeting mRNAs to different functional domains within neurons is crucial to memory storage. In Aplysia sensory neurons, syntaxin mRNA accumulates at the axon hillock during long-term facilitation of sensory-motor neuron synapses produced by serotonin (5-HT). We find that the 3' untranslated region of Aplysia syntaxin mRNA has two targeting elements, the cytosolic polyadenylation element (CPE) and stem-loop double-stranded structures that appear to interact with mRNA-binding proteins CPEB and Staufen. Blocking the interaction between these targeting elements and their RNA-binding proteins abolished both accumulation at the axon hillock and long-term facilitation. CPEB, which we previously have shown to be upregulated after stimulation with 5-HT, is required for the relocalization of syntaxin mRNA to the axon hillock from the opposite pole in the cell body of the sensory neuron during long-term facilitation, whereas Staufen is required for maintaining the accumulation of the mRNA both at the axon hillock after the treatment with 5-HT and at the opposite pole in stable, unstimulated sensory neurons. Thus, the cooperative actions of the two mRNA-binding proteins serve to direct the distribution of an mRNA encoding a key synaptic protein.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.