ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Differential susceptibility to synaptic plasticity reveals a functional specialization of ascending axon and parallel fiber synapses to cerebellar Purkinje cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Article
- Synaptic Activation of a Detailed Purkinje Cell Model Predicts Voltage-Dependent Control of Burst-Pause Responses in Active Dendrites.Frontiers in cellular neuroscience · 2017Article
- Oscillations, Timing, Plasticity, and Learning in the Cerebellum.Cerebellum (London, England) · 2016Review
- A use-dependent increase in release sites drives facilitation at calretinin-deficient cerebellar parallel-fiber synapses.Frontiers in cellular neuroscience · 2015Article
- Localization of Presynaptic Plasticity Mechanisms Enables Functional Independence of Synaptic and Ectopic Transmission in the Cerebellum.Neural plasticity · 2015Article
- Modeling possible effects of atypical cerebellar processing on eyeblink conditioning in autism.Cognitive, affective & behavioral neuroscience · 2014Article
- Activation of extrasynaptic NMDARs at individual parallel fiber-molecular layer interneuron synapses in cerebellum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- High frequency burst firing of granule cells ensures transmission at the parallel fiber to purkinje cell synapse at the cost of temporal coding.Frontiers in neural circuits · 2013Article
- Calcium influx measured at single presynaptic boutons of cerebellar granule cell ascending axons and parallel fibers.Cerebellum (London, England) · 2012Article
- Adaptation of granule cell to Purkinje cell synapses to high-frequency transmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Synchrony and neural coding in cerebellar circuits.Frontiers in neural circuits · 2012Article
- Article
- Crossing zones in the vestibulocerebellum: a commentary.Cerebellum (London, England) · 2011Article
- Ins and outs of cerebellar modules.Cerebellum (London, England) · 2011Article
- Long-term depression at parallel fiber to Golgi cell synapses.Journal of neurophysiology · 2010Article
- On the induction of postsynaptic granule cell-Purkinje neuron LTP and LTD.Cerebellum (London, England) · 2010Review
- Article
- Model-founded explorations of the roles of molecular layer inhibition in regulating purkinje cell responses in cerebellar cortex: more trouble for the beam hypothesis.Frontiers in cellular neuroscience · 2010Article
- High-Pass Filtering and Dynamic Gain Regulation Enhance Vertical Bursts Transmission along the Mossy Fiber Pathway of Cerebellum.Frontiers in cellular neuroscience · 2010Article
- The functional equivalence of ascending and parallel fiber inputs in cerebellar computation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
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2 authors.
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Abstract
Granule cell axons, via their parallel fibers, form synapses with Purkinje cells across large areas of the cerebellar cortex. Evidence for uniform transmission along parallel fibers to Purkinje cells is controversial, however, leading to speculation that the ascending axonal segment plays a dominant role in cerebellar processing. We have compared the relative susceptibilities of ascending axon and parallel fiber synaptic inputs to several forms of synaptic plasticity. We demonstrate that ascending axon synapses have a limited capability to undergo forms of long-term depression and potentiation compared with parallel fiber synapses. These results demonstrate that these two segments of the same axon play fundamentally different roles in cerebellar signaling, and, as such, the synapses formed between granule cells and Purkinje cells should not be treated as a homogenous population.
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Registered trials
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