ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
State-dependent AMPA receptor trafficking in the mammalian retina.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Localizing Proton-Mediated Inhibitory Feedback at the Retinal Horizontal Cell-Cone Synapse with Genetically-Encoded pH Probes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Trafficking of calcium-permeable and calcium-impermeable AMPA receptors in nucleus accumbens medium spiny neurons co-cultured with prefrontal cortex neurons.Neuropharmacology · 2017Article
- Kainate receptors mediate synaptic input to transient and sustained OFF visual pathways in primate retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Spatial organization of AMPAR subtypes in ON RGCs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Molecular mechanisms underlying activity-dependent AMPA receptor cycling in retinal ganglion cells.Molecular and cellular neurosciences · 2013Article
- Directional summation in non-direction selective retinal ganglion cells.PLoS computational biology · 2013Article
- Light-induced plasticity of synaptic AMPA receptor composition in retinal ganglion cells.Neuron · 2012Article
- Quantal amplitude at the cone ribbon synapse can be adjusted by changes in cytosolic glutamate.Molecular vision · 2011Article
- Calcium-permeable AMPA receptors in the retina.Frontiers in molecular neuroscience · 2011Article
- Glutamate-induced internalization of Ca(v)1.3 L-type Ca(2+) channels protects retinal neurons against excitotoxicity.The Journal of physiology · 2010Article
- Characterization of the transcripts and protein isoforms for cytoplasmic polyadenylation element binding protein-3 (CPEB3) in the mouse retina.BMC molecular biology · 2009Article
- Signaling logic of activity-triggered dendritic protein synthesis: an mTOR gate but not a feedback switch.PLoS computational biology · 2009Article
- Activity-dependent synaptic plasticity in retinal ganglion cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Robust syntaxin-4 immunoreactivity in mammalian horizontal cell processes.Visual neuroscienceArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The rapid cycling of AMPA receptors (AMPARs) at the membrane maintains synaptic transmission at a number of CNS synapses and may play a role in several forms of synaptic plasticity. It is unclear, however, how prevalent the trafficking of AMPARs is in the CNS, particularly at synapses not known to exhibit activity-dependent plasticity. Because trafficking is regulated by basal synaptic activity, a question also remains as to how receptor trafficking is modulated at synapses subject to different patterns of synaptic activation. We have investigated whether trafficking of AMPARs occurs in retinal neurons, which are subject to tonic glutamate release. We find two distinct states of AMPAR trafficking in ON ganglion cells. Light adaptation serves to stabilize AMPARs in a noncycling mode. However, dark adaptation for as little as 8 h triggers a switch to a second state of trafficking characterized by rapid cycling. We provide evidence that the activation of AMPARs is critical for switching between cycling and noncycling states. The induction of cycling further appears to be modulated by changes in the function of glutamate receptor 2/3-interacting proteins. Our results suggest that there is a strong link between synaptic activity and AMPAR trafficking in retinal neurons. These results further suggest the existence of a previously unknown form of activity-dependent plasticity in the retina that may be regulated in the course of a normal light/dark cycle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.