SynthesisJournal of general internal medicine2006
Brief report: Coronary heart disease events associated with hormone therapy in younger and older women. A meta-analysis.
Synthesis in Journal of general internal medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 94 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
94 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Combined effect of physical exercise and hormone replacement therapy on cardiovascular and metabolic health in postmenopausal women: A systematic review and meta-analysis.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023Pooled it
- Menopausal hormone therapy and women's health: An umbrella review.PLoS medicine · 2021Pooled it
- Hormone therapy for preventing cardiovascular disease in post-menopausal women.The Cochrane database of systematic reviews · 2015Pooled it
- The 2012 hormone therapy position statement of: The North American Menopause Society.Menopause (New York, N.Y.) · 2012Guideline
- Post-genomic update on a classical candidate gene for coronary artery disease: ESR1.Circulation. Cardiovascular genetics · 2011Pooled it
- Association between hormone replacement therapy and subsequent arterial and venous vascular events: a meta-analysis.European heart journal · 2008Pooled it
- Estrogen and progestogen use in postmenopausal women: July 2008 position statement of The North American Menopause Society.Menopause (New York, N.Y.)Guideline
- Effect of hormone therapy on tryptophan metabolism and atherosclerosis among postmenopausal women.Climacteric : the journal of the International Menopause Society · 2025Trial
- Effect of Hormone Therapy on Lipoprotein Subfractions in Early and Late Postmenopausal Women.The Journal of clinical endocrinology and metabolism · 2025Trial
- Trial
- Effect of menopausal hormone therapy on methylation levels in early and late postmenopausal women.Clinical epigenetics · 2022Trial
- Trial
- Effects of Estradiol Dose and Serum Estradiol Levels on Metabolic Measures in Early and Late Postmenopausal Women in the REPLENISH Trial.Journal of women's health (2002) · 2020Trial
- The Effect of Perimenopausal Transdermal Estradiol and Micronized Progesterone on Markers of Risk for Arterial Disease.The Journal of clinical endocrinology and metabolism · 2020Trial
- Differential Effect of Plasma Estradiol on Subclinical Atherosclerosis Progression in Early vs Late Postmenopause.The Journal of clinical endocrinology and metabolism · 2019Trial
- Vascular Effects of Early versus Late Postmenopausal Treatment with Estradiol.The New England journal of medicine · 2016Trial
- Methods and baseline cardiovascular data from the Early versus Late Intervention Trial with Estradiol testing the menopausal hormone timing hypothesis.Menopause (New York, N.Y.) · 2015Trial
- The mortality toll of estrogen avoidance: an analysis of excess deaths among hysterectomized women aged 50 to 59 years.American journal of public health · 2013Trial
- Health related quality of life after combined hormone replacement therapy: randomised controlled trial.BMJ (Clinical research ed.) · 2008Trial
- Main morbidities recorded in the women's international study of long duration oestrogen after menopause (WISDOM): a randomised controlled trial of hormone replacement therapy in postmenopausal women.BMJ (Clinical research ed.) · 2007Trial
34 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the effect of hormone therapy (HT) on coronary heart disease (CHD) events in younger and older postmenopausal women.
designA comprehensive database search identified randomized-controlled trials of HT of at least 6 months' duration that reported CHD events, defined as myocardial infarction or cardiac death. MEASUREMENTS: The pooled odds ratios (ORs) for CHD events were reported separately for younger and older women, defined as participants with mean time from menopause of less than or greater than 10 years, or mean age less than or greater than 60 years. MAIN
resultsPooled data from 23 trials, with 39,049 participants followed for 191,340 patient-years, showed that HT significantly reduced CHD events in younger women (OR 0.68 [confidence interval (C I), 0.48 to 0.96]), but not in older women (OR 1.03 [CI, 0.91 to 1.16]). Hormone therapy reduced events in younger women compared with older women (OR 0.66 [CI, 0.46 to 0.95]). In older women, HT increased events in the first year (OR 1.47 [CI, 1.12 to 1.92]), then reduced events after 2 years (OR 0.79 [CI, 0.67 to 0.93]).
conclusionsHormone therapy reduces the risk of CHD events in younger postmenopausal women. In older women, HT increases, then decreases risk over time.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.