ArticleAmerican journal of rhinology
Altered expression of genes associated with innate immunity and inflammation in recalcitrant rhinosinusitis with polyps.
Article in American journal of rhinology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00841802 (Glucocorticosteroid Action in Inflammatory Disease), which is not on this map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Glucocorticosteroid Action in Inflammatory Disease
Who cites it
48 citing papers in PubMed, 111 citations in OpenAlex.
- Differential expression of innate immunity genes in chronic rhinosinusitis.American journal of rhinology & allergyTrial
- TLR Signals in Epithelial Cells in the Nasal Cavity and Paranasal Sinuses.Frontiers in allergy · 2021Review
- Differential expression and role of S100 proteins in chronic rhinosinusitis.Current opinion in allergy and clinical immunology · 2020Review
- [Recent clinical advances in refractory chronic sinusitis].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2020Article
- C3a receptor antagonism as a novel therapeutic target for chronic rhinosinusitis.Mucosal immunology · 2018Article
- P-glycoprotein and chronic rhinosinusitis.World journal of otorhinolaryngology - head and neck surgery · 2018Review
- Calgranulin C (S100A12) Is Differentially Expressed in Subtypes of Chronic Rhinosinusitis.American journal of rhinology & allergy · 2018Observational
- Differences in RANTES and IL-6 levels among chronic rhinosinusitis patients with predominant gram-negative and gram-positive infection.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2017Article
- Biofilms in chronic rhinosinusitis: Pathophysiology and therapeutic strategies.World journal of otorhinolaryngology - head and neck surgery · 2016Review
- Different activations of toll-like receptors and antimicrobial peptides in chronic rhinosinusitis with or without nasal polyposis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Article
- A role for auto-immunity in chronic rhinosinusitis? Lessons learned from sub-epidermal bullous disorders of the skin.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2016Review
- A comprehensive review of the nasal microbiome in chronic rhinosinusitis (CRS).Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2016Review
- Cytokine patterns in nasal secretion of non-atopic patients distinguish between chronic rhinosinusitis with or without nasal polys.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2016Article
- Topical cathelicidin (LL-37) an innate immune peptide induces acute olfactory epithelium inflammation in a mouse model.International forum of allergy & rhinology · 2015Article
- Chronic rhinosinusitis pathogenesis.The Journal of allergy and clinical immunology · 2015Review
- Otolaryngology-head and neck surgery at Johns Hopkins: The first 100 years (1914-2014).The Laryngoscope · 2015Article
- Clinical and biological markers of difficult-to-treat severe chronic rhinosinusitis.Current allergy and asthma reports · 2015Review
- Involvement of Toll-like receptor 2 and epidermal growth factor receptor signaling in epithelial expression of airway remodeling factors.American journal of respiratory cell and molecular biology · 2015Article
- Pathogenesis of nasal polyposis.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2015Review
- Fungal extracts detected in eosinophilic chronic rhinosinusitis induced cytokines from the nasal polyp cells.The Laryngoscope · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe role of the innate immune system in the pathophysiology of chronic rhinosinusitis (CRS) is poorly understood. In this study, we compared sinonasal expression of toll-like receptors (TLRs), complement components, serum amyloid A, and inflammatory genes (chemokines and cytokines) in control subjects and patients undergoing sinus surgery for CRS.
methodsEleven control subjects and 30 subjects with CRS unresponsive to medical management were enrolled prospectively before undergoing endoscopic sinus surgery. Ethmoid mucosal specimens were obtained surgically and processed for RNA extraction. Real-time polymerase chain reaction was used to quantitate the level of expression of messenger RNA (mRNA) for TLR, acute phase proteins, and cytokine genes. Subjects were followed for a minimum of 6 months postoperatively with nasal endoscopy to assess for recurrence of polyps.
resultsmRNA for all target genes was detected in the ethmoid mucosa of both control and CRS subjects. The level of gene expression was normalized to the housekeeping genes 18s RNA and glyceraldehyde-3-phosphate dehydrogenase. As compared with controls, CRS was associated with significantly higher expression of TLR2 and the inflammatory genes macrophage-inflammatory protein alpha, RANTES, and granulocyte-macrophage colony-stimulating factor. Patients with early recurrence of polyps after surgery had significantly decreased expression of TLR2, 9, and serum amyloid A and increased expression of macrophage-inflammatory protein alpha compared with surgery-responsive patients.
conclusionThis study shows the increased levels of expression of TLR2 and a variety of inflammatory genes in sinonasal mucosa of CRS patients compared with controls. Whether these differences play a role in pathogenesis or are merely manifestations of disease activity is worthy of investigation.
Indexed as
Identifiers
16686375PMC2810150W12078422What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.