ArticleAmerican journal of human genetics2006
Online system for faster multipoint linkage analysis via parallel execution on thousands of personal computers.
Article in American journal of human genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Linkage analysis of a large African family segregating stuttering suggests polygenic inheritance.Human genetics · 2013Trial
- A ciliopathy combining Joubert syndrome and Oro-Facial-Digital syndrome caused by bi-allelic 5'-UTR loss-of-function CEP83 variant.NPJ genomic medicine · 2025Article
- Syntaxin 4 is essential for hearing in human and zebrafish.Human molecular genetics · 2023Article
- ADAMTS1, MPDZ, MVD, and SEZ6: candidate genes for autosomal recessive nonsyndromic hearing impairment.European journal of human genetics : EJHG · 2022Article
- Wolfram-like syndrome with bicuspid aortic valve due to a homozygous missense variant in CDK13.Journal of human genetics · 2021Article
- Linkage and exome analysis implicate multiple genes in non-syndromic intellectual disability in a large Swedish family.BMC medical genomics · 2019Article
- Hypomorphic caspase activation and recruitment domain 11 (CARD11) mutations associated with diverse immunologic phenotypes with or without atopic disease.The Journal of allergy and clinical immunology · 2019Article
- Novel missense and 3'-UTR splice site variants in LHFPL5 cause autosomal recessive nonsyndromic hearing impairment.Journal of human genetics · 2018Article
- Confirmation of the Role of DHX38 in the Etiology of Early-Onset Retinitis Pigmentosa.Investigative ophthalmology & visual science · 2018Article
- A novel homozygous variant in BMPR1B underlies acromesomelic dysplasia Hunter-Thompson type.Annals of human genetics · 2018Article
- Role of Segregation for Variant Discovery in Multiplex Families Ascertained by Probands With Left Sided Cardiovascular Malformations.Frontiers in genetics · 2018Article
- SLC30A9 mutation affecting intracellular zinc homeostasis causes a novel cerebro-renal syndrome.Brain : a journal of neurology · 2017Article
- Novel mutations in the genes TGM1 and ALOXE3 underlying autosomal recessive congenital ichthyosis.International journal of dermatology · 2016Article
- FOXE3 mutations predispose to thoracic aortic aneurysms and dissections.The Journal of clinical investigation · 2016Article
- Mutation of ATF6 causes autosomal recessive achromatopsia.Human genetics · 2015Article
- Biallelic mutations in the autophagy regulator DRAM2 cause retinal dystrophy with early macular involvement.American journal of human genetics · 2015Article
- Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with a loss-of-function mutation in CDK5.Human genetics · 2015Article
- FGF5 is a crucial regulator of hair length in humans.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Isolated foveal hypoplasia with secondary nystagmus and low vision is associated with a homozygous SLC38A8 mutation.European journal of human genetics : EJHG · 2014Article
- Recurrent gain-of-function mutation in PRKG1 causes thoracic aortic aneurysms and acute aortic dissections.American journal of human genetics · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Computation of LOD scores is a valuable tool for mapping disease-susceptibility genes in the study of Mendelian and complex diseases. However, computation of exact multipoint likelihoods of large inbred pedigrees with extensive missing data is often beyond the capabilities of a single computer. We present a distributed system called "SUPERLINK-ONLINE," for the computation of multipoint LOD scores of large inbred pedigrees. It achieves high performance via the efficient parallelization of the algorithms in SUPERLINK, a state-of-the-art serial program for these tasks, and through the use of the idle cycles of thousands of personal computers. The main algorithmic challenge has been to efficiently split a large task for distributed execution in a highly dynamic, nondedicated running environment. Notably, the system is available online, which allows computationally intensive analyses to be performed with no need for either the installation of software or the maintenance of a complicated distributed environment. As the system was being developed, it was extensively tested by collaborating medical centers worldwide on a variety of real data sets, some of which are presented in this article.
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