ArticleAmerican journal of human genetics2006
Multilocus association mapping using variable-length Markov chains.
Article in American journal of human genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.
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Who cites it
76 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genome-wide meta-analyses of smoking behaviors in African Americans.Translational psychiatry · 2012Pooled it
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- A UNIFIED FRAMEWORK FOR VARIANCE COMPONENT ESTIMATION WITH SUMMARY STATISTICS IN GENOME-WIDE ASSOCIATION STUDIES.The annals of applied statistics · 2017Article
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- FAPI: Fast and accurate P-value Imputation for genome-wide association study.European journal of human genetics : EJHG · 2016Article
- Genomic Characterization of a South American Phytophthora Hybrid Mandates Reassessment of the Geographic Origins of Phytophthora infestans.Molecular biology and evolution · 2016Article
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- Whole genome SNP genotype piecemeal imputation.BMC bioinformatics · 2015Article
- Genome-wide haplotypic testing in a Finnish cohort identifies a novel association with low-density lipoprotein cholesterol.European journal of human genetics : EJHG · 2015Article
- A spatial haplotype copying model with applications to genotype imputation.Journal of computational biology : a journal of computational molecular cell biology · 2015Article
- Prospects and limits of marker imputation in quantitative genetic studies in European elite wheat (Triticum aestivum L.).BMC genomics · 2015Article
- Predicting haplotype carriers from SNP genotypes in Bos taurus through linear discriminant analysis.Genetics, selection, evolution : GSE · 2015Article
- Parente2: a fast and accurate method for detecting identity by descent.Genome research · 2015Article
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- Pedigree-Free Descent-Based Gene Mapping from Population Samples.Human heredity · 2015Article
- Big data challenges in bone research: genome-wide association studies and next-generation sequencing.BoneKEy reports · 2015Article
- Disease mechanisms in rheumatology--tools and pathways: defining functional genetic variants in autoimmune diseases.Arthritis & rheumatology (Hoboken, N.J.) · 2015Review
16 more citing papers are in PubMed but not listed here.
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1 author.
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Abstract
I propose a new method for association-based gene mapping that makes powerful use of multilocus data, is computationally efficient, and is straightforward to apply over large genomic regions. The approach is based on the fitting of variable-length Markov chain models, which automatically adapt to the degree of linkage disequilibrium (LD) between markers to create a parsimonious model for the LD structure. Edges of the fitted graph are tested for association with trait status. This approach can be thought of as haplotype testing with sophisticated windowing that accounts for extent of LD to reduce degrees of freedom and number of tests while maximizing information. I present analyses of two published data sets that show that this approach can have better power than single-marker tests or sliding-window haplotypic tests.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.