Trial reportEuropean journal of applied physiology2006
The effect of 2 weeks vitamin C supplementation on immunoendocrine responses to 2.5 h cycling exercise in man.
Trial report in European journal of applied physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Effects of vitamin C on oxidative stress, inflammation, muscle soreness, and strength following acute exercise: meta-analyses of randomized clinical trials.European journal of nutrition · 2020Pooled it
- Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases.The Cochrane database of systematic reviews · 2012Pooled it
- Effects of acute bovine colostrum supplementation on immune responses to prolonged cycling: a randomised crossover trial.European journal of nutrition · 2026Trial
- The effect of acute pre-exercise dark chocolate consumption on plasma antioxidant status, oxidative stress and immunoendocrine responses to prolonged exercise.European journal of nutrition · 2012Trial
- Exploring the Relationship between Micronutrients and Athletic Performance: A Comprehensive Scientific Systematic Review of the Literature in Sports Medicine.Sports (Basel, Switzerland) · 2023Review
- Nutritional Compounds to Improve Post-Exercise Recovery.Nutrients · 2022Review
- Effects of Functional Phenolics Dietary Supplementation on Athletes' Performance and Recovery: A Review.International journal of molecular sciences · 2022Review
- A Short Overview of Changes in Inflammatory Cytokines and Oxidative Stress in Response to Physical Activity and Antioxidant Supplementation.Antioxidants (Basel, Switzerland) · 2020Review
- Review
- Article
- Can Match-Mimicking Intermittent Practice Be Used as a Simulatory Training Mode of Competition Using Olympic Time Frame in Elite Taekwondo Athletes?Frontiers in physiology · 2019Article
- The influence of a hot environment on physiological stress responses in exercise until exhaustion.PloS one · 2019Article
- Self-Care for Common Colds: The Pivotal Role of Vitamin D, Vitamin C, Zinc, andEvidence-based complementary and alternative medicine : eCAM · 2018Review
- Immunological aspects of sport nutrition.Immunology and cell biology · 2016Review
- Polyphenols in exercise performance and prevention of exercise-induced muscle damage.Oxidative medicine and cellular longevity · 2013Review
- Salivary antimicrobial peptides (LL-37 and alpha-defensins HNP1-3), antimicrobial and IgA responses to prolonged exercise.European journal of applied physiology · 2009Article
- Does antioxidant vitamin supplementation protect against muscle damage?Sports medicine (Auckland, N.Z.) · 2009Review
- Recovery after an Ironman triathlon: sustained inflammatory responses and muscular stress.European journal of applied physiology · 2008Article
- Alterations of immunoendocrine responses during the recovery period after acute prolonged cycling.European journal of applied physiology · 2007Article
- Response to Hemilä. Did not record upper respiratory tract infection (URTI) symptoms/episodes.European journal of applied physiology · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An increased systemic concentration of stress hormones (of the hypothalamic-pituitary adrenal axis) and some cytokines may contribute to the depression of immune cell function typically observed after prolonged exercise. The aim of the present study was to determine the effect of 2 weeks of supplementation with vitamin C (VC) on cortisol, adrenocorticotrophic hormone, interleukin-6, oxidative stress and neutrophil responses to a single bout of endurance exercise. Nine healthy endurance-trained males exercised for 2.5 h at 60% VO2max after 2 weeks of placebo (PLA) or VC (1,000 mg day(-1)) supplementation. All participants completed both trials utilising a randomised crossover design with a minimum 14 day washout period between trials. There was a significant trial x time interaction effect for plasma cortisol concentration (P = 0.039) which tended to be lower in the VC trial but post hoc analysis found no specific between trial differences. There was a significantly lower post-exercise neutrophilia (P < 0.014) in the VC trial, compared with the PLA trial. There was no trial x time interaction for measures of neutrophil function (bacteria-stimulated elastase release, fMLP or PMA-stimulated oxidative burst). However, there was a trend for higher fMLP-stimulated neutrophil oxidative burst in the VC compared with PLA trial (trial x time interaction, P = 0.075). These results suggest that supplementation with VC for a period of up to 2 weeks provides little to no protection against the depression of neutrophil function which typically occurs after endurance exercise.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.