ReviewMolecular neurobiology1991
The regulation and function of protein phosphatases in the brain.
Review in Molecular neurobiology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 56 citations in OpenAlex.
- Protein Phosphatase 2A: a Double-Faced Phosphatase of Cellular System and Its Role in Neurodegenerative Disorders.Molecular neurobiology · 2018Review
- Article
- Curcumin treatment recovery the decrease of protein phosphatase 2A subunit B induced by focal cerebral ischemia in Sprague-Dawley rats.Laboratory animal research · 2015Article
- Protein phosphatase 2A is involved in the tyrosine hydroxylase phosphorylation regulated by α-synuclein.Neurochemical research · 2015Article
- Ferulic acid attenuates the injury-induced decrease of protein phosphatase 2A subunit B in ischemic brain injury.PloS one · 2013Article
- Lewy-like aggregation of α-synuclein reduces protein phosphatase 2A activity in vitro and in vivo.Neuroscience · 2012Article
- Peptidyl-prolyl isomerase 1 regulates protein phosphatase 2A-mediated topographic phosphorylation of neurofilament proteins.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Signal transduction therapeutics: relevance for Alzheimer's disease.Journal of molecular neuroscience : MN · 2004Review
- Effects of prenatal exposure to cocaine on the developing brain: anatomical, chemical, physiological and behavioral consequences.Neurotoxicity research · 2001Article
- Modulation of phosphorylation of neuronal cytoskeletal proteins by neuronal depolarization.Cellular and molecular neurobiology · 1997Article
- Cytoskeletal-associated protein kinase and phosphatase activities from cerebral cortex of young rats.Neurochemical research · 1995Article
- Autophosphorylation of neuronal calcium/calmodulin-stimulated protein kinase II.Molecular neurobiology · 1991Review
- The role of protein kinase C and its neuronal substrates dephosphin, B-50, and MARCKS in neurotransmitter release.Molecular neurobiology · 1991Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Data emerging from a number of different systems indicate that protein phosphatases are highly regulated and potentially responsive to changes in the levels of intracellular second messengers produced by extracellular stimulation. They may therefore be involved in the regulation of many cell functions. The protein phosphatases in the nervous system have not been well studied. However, a number of neuronal-specific regulators (such as DARPP-32 and G-substrate) exist, and brain protein phosphatases appear to have particularly low specific activity, suggesting that neuronal protein phosphatases possess considerable and unique potential for regulation. Several early events following depolarization or receptor activation appear to involve specific dephosphorylations, indicating that regulation of protein phosphatase activity is important for the control of many neuronal functions. This article reviews the current literature concerning the identification, regulation, and function of serine/threonine protein phosphatases in the brain, with particular emphasis on the regulation of the major protein phosphatases, PP1 and PP2A, and their potential roles in modulating neurotransmitter release and postsynaptic responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.