ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2006
Phase of the menstrual cycle does not affect orthostatic tolerance in healthy women.
Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 46 citations in OpenAlex.
- Low-dose morphine reduces tolerance to central hypovolemia in healthy adults without affecting muscle sympathetic outflow.American journal of physiology. Heart and circulatory physiology · 2022Trial
- Menstrual cycle alters sympathetic neural responses to orthostatic stress in young, eumenorrheic women.American journal of physiology. Endocrinology and metabolism · 2009Trial
- Cutaneous postural vasoconstriction is modified by exogenous but not endogenous female hormones in young women.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2007Trial
- Article
- Short-Term Cardiovascular Compensatory Responses to Varying Levels of Orthostatic Stress During Active Standing in Older Adults.Journal of clinical medicine · 2025Article
- Changes in Autonomic Balance, Cardiac Parasympathetic Modulation, and Cardiac Baroreflex Gain in Older Adults Under Different Orthostatic Stress Conditions.Healthcare (Basel, Switzerland) · 2025Article
- Implications of sex differences in orthostatic tolerance during exposure to acute artificial gravity.NPJ microgravity · 2025Article
- Effects of menstrual cycle on hemodynamic and autonomic responses to central hypovolemia.Frontiers in cardiovascular medicine · 2024Article
- Cerebral autoregulation across the menstrual cycle in eumenorrheic women.Physiological reports · 2022Article
- The Specificities of Elite Female Athletes: A Multidisciplinary Approach.Life (Basel, Switzerland) · 2021Review
- Hydration Status and Cardiovascular Function.Nutrients · 2019Review
- Mechanisms contributing to low orthostatic tolerance in women: the influence of oestradiol.The Journal of physiology · 2013Article
- Article
- Identical pattern of cerebral hypoperfusion during different types of syncope.Journal of human hypertension · 2010Article
- Autonomic reactivity to pain throughout the menstrual cycle in healthy women.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2009Article
- Effects of ovarian hormones and aging on respiratory sinus arrhythmia and breathing patterns in women.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Women of child-bearing age have a lower orthostatic tolerance (OT) than older women or men, and women suffering from frequent syncopal episodes often comment that their symptoms occur at certain times of the menstrual cycle. However, it is not known whether, in asymptomatic women, OT varies at different phases of the menstrual cycle. We studied 8 healthy asymptomatic women aged 26.8 +/- 3.4 years. We determined OT using a test of combined head-up tilting and lower body suction. We continuously monitored beat-to-beat blood pressure (Finapres), heart rate (ECG), and cerebral and forearm blood flow velocities (Doppler ultrasound). On each test day we assessed carotid baroreceptor sensitivity from suction/pressure applied to a neck chamber. We also determined estradiol and progesterone levels from a venous blood sample. Tests were performed in early follicular and late luteal phases, and during ovulation. Serum concentrations of estradiol (pmol x l(-1)) and progesterone (nmol x l(-1)) were in follicular phase 464.1 +/- 63 and 6.3 +/- 2.8; ovulation 941.6 +/- 298 and 5.8 +/- 1.2; luteal phase 698 +/- 188 and 32.3 +/- 9.6. Progesterone levels were significantly higher in the luteal phase (p < 0.001). OT was not different on any test day: follicular 31.9 +/- 1.6 min, ovulation 31.3 +/- 0.7 min; luteal 31.1 +/- 2.2 min. Supine and tilted heart rates and blood pressures, the maximum heart rate, and the cerebral autoregulatory and forearm vascular resistance responses to the orthostatic stress were similar during all studies. Both cardiac and vascular resistance carotid baroreceptor sensitivities were also similar on all test days. These results suggest that there is no difference in either OT or cardiovascular control at the tested phases of the menstrual cycle in healthy women.
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Registered trials
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