Evidence map›Paper›PMID 16683036›Full record

ArticlePLoS genetics2006

Transcript annotation in FANTOM3: mouse gene catalog based on physical cDNAs.

Norihiro Maeda, Takeya Kasukawa, Rieko Oyama, Julian Gough, Martin Frith, Pär G Engström, Boris Lenhard, Rajith N Aturaliya, Serge Batalov, Kirk W Beisel and 24 more

Abstract read
In one paragraph

Article in PLoS genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. The Role of Long Intergenic Noncoding RNA in Fetal Development.International journal of molecular sciences · 2024
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Non-coding antisense transcripts: fine regulation of gene expression in cancer.Computational and structural biotechnology journal · 2022
    Review
  10. Methods for the Study of Long Noncoding RNA in Cancer Cell Signaling.Methods in molecular biology (Clifton, N.J.) · 2021
    Article
  11. Long Non-Coding RNAFrontiers in cell and developmental biology · 2021
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. The functions and unique features of long intergenic non-coding RNA.Nature reviews. Molecular cell biology · 2018
    Review

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Norihiro MaedaGenome Science Laboratory, Discovery Research Institute, RIKEN Wako Institute, Wako, Japan. rgscerg@gsc.riken.jp
Takeya Kasukawa
Rieko Oyama
Julian Gough
Martin Frith
Pär G Engström
Boris Lenhard
Rajith N Aturaliya
Serge Batalov
Kirk W Beisel
Carol J Bult
Colin F Fletcher
Alistair R R Forrest
Masaaki Furuno
David Hill
Masayoshi Itoh
Mutsumi Kanamori-Katayama
Shintaro Katayama
Masaru Katoh
Tsugumi Kawashima
John Quackenbush
Timothy Ravasi
Brian Z Ring
Kazuhiro Shibata
Koji Sugiura
Yoichi Takenaka
Rohan D Teasdale
Christine A Wells
Yunxia Zhu
Chikatoshi Kai
Jun Kawai
David A Hume
Piero Carninci
Yoshihide Hayashizaki

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The international FANTOM consortium aims to produce a comprehensive picture of the mammalian transcriptome, based upon an extensive cDNA collection and functional annotation of full-length enriched cDNAs. The previous dataset, FANTOM2, comprised 60,770 full-length enriched cDNAs. Functional annotation revealed that this cDNA dataset contained only about half of the estimated number of mouse protein-coding genes, indicating that a number of cDNAs still remained to be collected and identified. To pursue the complete gene catalog that covers all predicted mouse genes, cloning and sequencing of full-length enriched cDNAs has been continued since FANTOM2. In FANTOM3, 42,031 newly isolated cDNAs were subjected to functional annotation, and the annotation of 4,347 FANTOM2 cDNAs was updated. To accomplish accurate functional annotation, we improved our automated annotation pipeline by introducing new coding sequence prediction programs and developed a Web-based annotation interface for simplifying the annotation procedures to reduce manual annotation errors. Automated coding sequence and function prediction was followed with manual curation and review by expert curators. A total of 102,801 full-length enriched mouse cDNAs were annotated. Out of 102,801 transcripts, 56,722 were functionally annotated as protein coding (including partial or truncated transcripts), providing to our knowledge the greatest current coverage of the mouse proteome by full-length cDNAs. The total number of distinct non-protein-coding transcripts increased to 34,030. The FANTOM3 annotation system, consisting of automated computational prediction, manual curation, and final expert curation, facilitated the comprehensive characterization of the mouse transcriptome, and could be applied to the transcriptomes of other species.

Indexed as

Databases, GeneticTranscription, GeneticAnimalsAutomationDNA, ComplementaryGenomeMiceDNA, Complementary

Identifiers

PMID16683036
PMCPMC1449903

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.