ArticlePLoS computational biology2006
Changing cellular location of CheZ predicted by molecular simulations.
Article in PLoS computational biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Correlation of CheY-P concentration and motor behavior during attractant adaptation in singleScience advances · 2026Article
- Fluctuations in Intracellular CheY-P Concentration Coordinate Reversals of Flagellar Motors inBiomolecules · 2020Article
- Allosteric Priming of E. coli CheY by the Flagellar Motor Protein FliM.Biophysical journal · 2020Article
- Probing chemotaxis activity in Escherichia coli using fluorescent protein fusions.Scientific reports · 2019Article
- Mathematical Analysis of the Escherichia coli Chemotaxis Signalling Pathway.Bulletin of mathematical biology · 2018Article
- Ultrasensitivity and fluctuations in the Barkai-Leibler model of chemotaxis receptors in Escherichia coli.PloS one · 2017Article
- Helicobacter pylori CheZ(HP) and ChePep form a novel chemotaxis-regulatory complex distinct from the core chemotaxis signaling proteins and the flagellar motor.Molecular microbiology · 2015Article
- Single-cell E. coli response to an instantaneously applied chemotactic signal.Biophysical journal · 2014Article
- The HtrA protease of Borrelia burgdorferi degrades outer membrane protein BmpD and chemotaxis phosphatase CheX.Molecular microbiology · 2013Article
- Excitation and adaptation in bacteria-a model signal transduction system that controls taxis and spatial pattern formation.International journal of molecular sciences · 2013Article
- Article
- Coordinated regulation of multiple flagellar motors by theBiophysics (Nagoya-shi, Japan) · 2012Review
- Exploring the spatial and temporal organization of a cell's proteome.Journal of structural biology · 2011Review
- Origins and diversification of a complex signal transduction system in prokaryotes.Science signaling · 2010Article
- Detailed simulations of cell biology with Smoldyn 2.1.PLoS computational biology · 2010Article
- Accurate particle-based simulation of adsorption, desorption and partial transmission.Physical biology · 2009Article
- Protein domains and residues involved in the CheZ/CheAS interaction.Journal of bacteriology · 2009Article
- Differential affinity and catalytic activity of CheZ in E. coli chemotaxis.PLoS computational biology · 2009Article
- Dynamic map of protein interactions in the Escherichia coli chemotaxis pathway.Molecular systems biology · 2009Article
- Adaptive dynamics with a single two-state protein.Journal of the Royal Society, Interface · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
In the chemotaxis pathway of the bacterium Escherichia coli, signals are carried from a cluster of receptors to the flagellar motors by the diffusion of the protein CheY-phosphate (CheYp) through the cytoplasm. A second protein, CheZ, which promotes dephosphorylation of CheYp, partially colocalizes with receptors in the plasma membrane. CheZ is normally dimeric in solution but has been suggested to associate into highly active oligomers in the presence of CheYp. A model is presented here and supported by Brownian dynamics simulations, which accounts for these and other experimental data: A minority component of the receptor cluster (dimers of CheA(short)) nucleates CheZ oligomerization and CheZ molecules move from the cytoplasm to a bound state at the receptor cluster depending on the current level of cellular stimulation. The corresponding simulations suggest that dynamic CheZ localization will sharpen cellular responses to chemoeffectors, increase the range of detectable ligand concentrations, and make adaptation more precise and robust. The localization and activation of CheZ constitute a negative feedback loop that provides a second tier of adaptation to the system. Subtle adjustments of this kind are likely to be found in many other signaling pathways.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.