ArticlePLoS computational biology2006
Positive selection, relaxation, and acceleration in the evolution of the human and chimp genome.
Article in PLoS computational biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 1 of them a synthesis that pooled it.
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78 citing papers in PubMed, 1 synthesis or guideline pooled it, 153 citations in OpenAlex.
- Recent adaptive events in human brain revealed by meta-analysis of positively selected genes.PloS one · 2013Pooled it
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- The Chimpanzee Brainnetome Atlas reveals distinct connectivity and gene expression profiles relative to humans.Innovation (Cambridge (Mass.)) · 2025Article
- Analysis of Evolutionary Conservation, Expression Level, and Genetic Association at a Genome-wide Scale Reveals Heterogeneity Across Polygenic Phenotypes.Molecular biology and evolution · 2024Article
- Comparative Analysis of Human-Chimpanzee Divergence in Brain Connectivity and its Genetic Correlates.bioRxiv : the preprint server for biology · 2024Article
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- Hearing loss genes reveal patterns of adaptive evolution at the coding and non-coding levels in mammals.BMC biology · 2021Article
- Characterization and Analysis of the Mitochondrial Genome of Common Bean (International journal of molecular sciences · 2020Article
- Relaxed constraint and functional divergence of the progesterone receptor (PGR) in the human stem-lineage.PLoS genetics · 2020Article
- Evolution of Brain Active Gene Promoters in Human Lineage Towards the Increased Plasticity of Gene Regulation.Molecular neurobiology · 2018Article
- Transcriptome Signatures of Selection, Drift, Introgression, and Gene Duplication in the Evolution of an Extremophile Endemic Plant.Genome biology and evolution · 2017Article
- Detection of Regional Variation in Selection Intensity within Protein-Coding Genes Using DNA Sequence Polymorphism and Divergence.Molecular biology and evolution · 2017Article
- Mutation-profile-based methods for understanding selection forces in cancer somatic mutations: a comparative analysis.Oncotarget · 2017Article
- Adaptive molecular evolution ofEcology and evolution · 2017Article
- PosiGene: automated and easy-to-use pipeline for genome-wide detection of positively selected genes.Nucleic acids research · 2017Article
- Detection of Pathways Affected by Positive Selection in Primate Lineages Ancestral to Humans.Molecular biology and evolution · 2017Article
- Function and evolution of a Lotus japonicus AP2/ERF family transcription factor that is required for development of infection threads.DNA research : an international journal for rapid publication of reports on genes and genomes · 2017Article
- Secreted Proteins Defy the Expression Level-Evolutionary Rate Anticorrelation.Molecular biology and evolution · 2017Article
- Changes in selective pressures associated with human population expansion may explain metabolic and immune related pathways enriched for signatures of positive selection.BMC genomics · 2016Article
- 267 Spanish Exomes Reveal Population-Specific Differences in Disease-Related Genetic Variation.Molecular biology and evolution · 2016Article
18 more citing papers are in PubMed but not listed here.
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3 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For years evolutionary biologists have been interested in searching for the genetic bases underlying humanness. Recent efforts at a large or a complete genomic scale have been conducted to search for positively selected genes in human and in chimp. However, recently developed methods allowing for a more sensitive and controlled approach in the detection of positive selection can be employed. Here, using 13,198 genes, we have deduced the sets of genes involved in rate acceleration, positive selection, and relaxation of selective constraints in human, in chimp, and in their ancestral lineage since the divergence from murids. Significant deviations from the strict molecular clock were observed in 469 human and in 651 chimp genes. The more stringent branch-site test of positive selection detected 108 human and 577 chimp positively selected genes. An important proportion of the positively selected genes did not show a significant acceleration in rates, and similarly, many of the accelerated genes did not show significant signals of positive selection. Functional differentiation of genes under rate acceleration, positive selection, and relaxation was not statistically significant between human and chimp with the exception of terms related to G-protein coupled receptors and sensory perception. Both of these were over-represented under relaxation in human in relation to chimp. Comparing differences between derived and ancestral lineages, a more conspicuous change in trends seems to have favored positive selection in the human lineage. Since most of the positively selected genes are different under the same functional categories between these species, we suggest that the individual roles of the alternative positively selected genes may be an important factor underlying biological differences between these species.
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