ArticleOncogene2006
Suppression of replication fork progression in low-dose-specific p53-dependent S-phase DNA damage checkpoint.
Article in Oncogene, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
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- A comparison of radiation-induced mitochondrial damage between neural progenitor stem cells and differentiated cells.Cell cycle (Georgetown, Tex.) · 2017Article
- ATM-mediated mitochondrial damage response triggered by nuclear DNA damage in normal human lung fibroblasts.Cell cycle (Georgetown, Tex.) · 2017Article
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- Severe mitochondrial damage associated with low-dose radiation sensitivity in ATM- and NBS1-deficient cells.Cell cycle (Georgetown, Tex.) · 2016Article
- RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells.Nucleic acids research · 2015Article
- DNA damage signaling guards against perturbation of cyclin D1 expression triggered by low-dose long-term fractionated radiation.Oncogenesis · 2014Article
- Nuclear accumulation of cyclin D1 following long-term fractionated exposures to low-dose ionizing radiation in normal human diploid cells.Cell cycle (Georgetown, Tex.) · 2014Article
- Cyclin D1 overexpression perturbs DNA replication and induces replication-associated DNA double-strand breaks in acquired radioresistant cells.Cell cycle (Georgetown, Tex.) · 2013Article
- Activation of the AKT/cyclin D1/Cdk4 survival signaling pathway in radioresistant cancer stem cells.Oncogenesis · 2012Article
- Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1.Cell death & disease · 2011Article
- 11q21.1-11q23.3 Is a site of intrinsic genomic instability triggered by irradiation.Genes, chromosomes & cancer · 2010Article
- Regulation of DNA replication by the S-phase DNA damage checkpoint.Cell division · 2009Article
- Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The S-phase DNA damage checkpoint is activated by DNA damage to delay DNA synthesis allowing time to resolve the replication block. We previously discovered the p53-dependent S-phase DNA damage checkpoint in mouse zygotes fertilized with irradiated sperm. Here, we report that the same p53 dependency holds in mouse embryonic fibroblasts (MEFs) at low doses of irradiation. DNA synthesis in p53 wild-type (WT) MEFs was suppressed in a biphasic manner in which a sharp decrease below 2.5 Gy was followed by a more moderate decrease up to 10 Gy. In contrast, p53-/- MEFs exhibited radioresistant DNA synthesis below 2.5 Gy whereas the cells retained the moderate suppression above 5 Gy. DNA fiber analysis revealed that 1 Gy irradiation suppressed replication fork progression in p53 WT MEFs, but not in p53-/- MEFs. Proliferating cell nuclear antigen (PCNA), clamp loader of DNA polymerase, was phosphorylated in WT MEFs after 1 Gy irradiation and redistributed to form foci in the nuclei. In contrast, PCNA was not phosphorylated and dissociated from chromatin in 1 Gy-irradiated p53-/- MEFs. These results demonstrate that the novel low-dose-specific p53-dependent S-phase DNA damage checkpoint is likely to regulate the replication fork movement through phosphorylation of PCNA.
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Registered trials
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