ArticleOncogene2006
SEPT2 is a new fusion partner of MLL in acute myeloid leukemia with t(2;11)(q37;q23).
Article in Oncogene, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 52 citations in OpenAlex.
- Trial
- Pediatric M5 acute myeloid leukemia withLeukemia research reports · 2021Article
- MicroRNA‑744‑5p is downregulated in colorectal cancer and targets SEPT2 to suppress the malignant phenotype.Molecular medicine reports · 2021Article
- Article
- Acute myeloid leukemia withSAGE open medical case reports · 2018Article
- Septin 9_i2 is downregulated in tumors, impairs cancer cell migration and alters subnuclear actin filaments.Scientific reports · 2017Article
- Therapeutic targeting the cell division cycle 25 (CDC25) phosphatases in human acute myeloid leukemia--the possibility to target several kinases through inhibition of the various CDC25 isoforms.Molecules (Basel, Switzerland) · 2014Review
- Genetic and clinical characterization of 45 acute leukemia patients with MLL gene rearrangements from a single institution.Molecular oncology · 2012Article
- Proteomic analysis of gastric cancer and immunoblot validation of potential biomarkers.World journal of gastroenterology · 2012Article
- Cell cycle control in acute myeloid leukemia.American journal of cancer research · 2012Article
- Article
- Rapid and quantitative imaging of excitation polarized fluorescence reveals ordered septin dynamics in live yeast.Biophysical journal · 2011Article
- Conquering the complex world of human septins: implications for health and disease.Clinical genetics · 2010Review
- Both SEPT2 and MLL are down-regulated in MLL-SEPT2 therapy-related myeloid neoplasia.BMC cancer · 2009Article
- A variant-type MLL/SEPT9 fusion transcript in adult de novo acute monocytic leukemia (M5b) with t(11;17)(q23;q25).International journal of hematology · 2008Article
- Characterization of a SEPT9 interacting protein, SEPT14, a novel testis-specific septin.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have identified a new mixed lineage leukemia (MLL) gene fusion partner in a patient with treatment-related acute myeloid leukemia (AML) presenting a t(2;11)(q37;q23) as the only cytogenetic abnormality. Fluorescence in situ hybridization demonstrated a rearrangement of the MLL gene and molecular genetic analyses identified a septin family gene, SEPT2, located on chromosome 2q37, as the fusion partner of MLL. RNA and DNA analyses showed the existence of an in-frame fusion of MLL exon 7 with SEPT2 exon 3, with the genomic breakpoints located in intron 7 and 2 of MLL and SEPT2, respectively. Search for DNA sequence motifs revealed the existence of two sequences with 94.4% homology with the topoisomerase II consensus cleavage site in MLL intron 7 and SEPT2 intron 2. SEPT2 is the fifth septin family gene fused with MLL, making this gene family the most frequently involved in MLL-related AML (about 10% of all known fusion partners). The protein encoded by SEPT2 is highly homologous to septins 1, 4 and 5 and is involved in the coordination of several key steps of mitosis. Further studies are warranted to understand why the septin protein family is particularly involved in the pathogenesis of MLL-associated leukemia.
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