ArticleProceedings of the National Academy of Sciences of the United States of America2006
Light chain inclusion permits terminal B cell differentiation and does not necessarily result in autoreactivity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Reprogramming human B cells with custom heavy-chain antibodies.Nature biomedical engineering · 2024Article
- Sequence-Based Discovery Demonstrates That Fixed Light Chain Human Transgenic Rats Produce a Diverse Repertoire of Antigen-Specific Antibodies.Frontiers in immunology · 2018Article
- Efficient AID targeting of switch regions is not sufficient for optimal class switch recombination.Nature communications · 2015Article
- Positive selection of natural poly-reactive B cells in the periphery occurs independent of heavy chain allelic inclusion.PloS one · 2015Article
- Role of the Igh intronic enhancer Eμ in clonal selection at the pre-B to immature B cell transition.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Identification of Igsigma and Iglambda in channel catfish, Ictalurus punctatus, and Iglambda in Atlantic cod, Gadus morhua.Immunogenetics · 2009Article
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
Mice in which the Jkappa cluster was replaced with a VkappaJkappa rearranged gene were studied. More than 90% of B cells from homozygous mutant mice expressed the transgenic kappa chain but showed a slightly reduced level of kappa transcripts compared with WT B lymphocytes. Light chain inclusion was apparent in 10% of B cells from these mice and raised 25% in hemizygous mice with a still lower expression of the knockin kappa chain. Beyond the rules of clonal selection, peripheral B cells developed in such animals, with included cells being activated and differentiating into class-switched or antibody-secreting cells. The high amount of included mature B cells was associated with an increase of hybrid kappa/lambda immunoglobulins but not with the increased prevalence of autoantibodies. Altogether, these data suggest that light chain exclusion prevalent in normal B cells mostly results from ordered rearrangements and stochastic mechanisms but is neither tightly ensured by a stringent cell selection process nor absolutely required for normal B cell function.
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