Evidence map›Paper›PMID 16682566›Full record

ArticleRNA (New York, N.Y.)2006

An mRNA sequence derived from a programmed frameshifting signal decreases codon discrimination during translation initiation.

Ana Raman, Carla Guarraia, Dwayne Taliaferro, Guillaume Stahl, Philip J Farabaugh

Open access · bronzeAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA (New York, N.Y.), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Ana Raman
Carla Guarraia
Dwayne Taliaferro
Guillaume Stahl
Philip J Farabaugh
University of Maryland, Baltimore County · USCentre National de la Recherche Scientifique · FR

Funding

The genetics of ribosomal reading frame maintenanceR01GM029480 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI FARABAUGH, PHILIP JAMES · 1985 to 2010
$2.7M
Molecular genetics of translational accuracyR56GM029480 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI FARABAUGH, PHILIP JAMES · 2007 to 2007
$323k
NIGMS NIH HHS GM 29480NIGMS NIH HHS R01 GM029480NIGMS NIH HHS R56 GM029480
6 · The paper itself

Abstract

Sequences and structures in the mRNA can alter the accuracy of translation. In some cases, mRNA secondary structures like hairpin loops or pseudoknots can cause frequent errors of translational reading frame (programmed frameshifting) or misreading of termination codons as sense (nonsense readthrough). In other cases, the primary mRNA sequence stimulates the error probably by interacting with an element of the ribosome to interfere with error correction. One such primary mRNA sequence, the Ty3 stimulator, increases programmed +1 frameshifting 7.5 times in the yeast Saccharomyces cerevisiae. Here we show that this stimulator also increases the usage of non-AUG initiation codons in the bacterium Escherichia coli but not in S. cerevisiae. These data suggest that in E. coli, though not in yeast, an element of the ribosome's elongation accuracy mechanism ensures initiation accuracy.

Indexed as

Peptide Chain Initiation, TranslationalBase Sequencebeta-GalactosidaseCodonEscherichia coliFrameshifting, RibosomalGenes, ReporterPlasmidsRNA, BacterialRNA, FungalRNA, MessengerSaccharomyces cerevisiaebeta-GalactosidaseCodonRNA, BacterialRNA, FungalRNA, Messenger

Identifiers

PMID16682566
PMCPMC1484443
OpenAlexW2169588394

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.