ArticleThe Journal of cell biology2006
E-cadherin engagement stimulates proliferation via Rac1.
Article in The Journal of cell biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 101 citations in OpenAlex.
- Substrates mimicking the blastocyst geometry revert pluripotent stem cell to naivety.Nature materials · 2024Article
- Rac1 promotes kidney collecting duct repair by mechanically coupling cell morphology to mitotic entry.Science advances · 2024Article
- Adhesion strength between cells regulate nonmonotonic growth by a biomechanical feedback mechanism.Biophysical journal · 2022Article
- Anti-Malignant Effect of Tensile Loading to Adherens Junctions in Cutaneous Squamous Cell Carcinoma Cells.Frontiers in cell and developmental biology · 2021Article
- Coordination between Cell Motility and Cell Cycle Progression in Keratinocyte Sheets via Cell-Cell Adhesion and Rac1.iScience · 2020Article
- Non-junctional role of Cadherin3 in cell migration and contact inhibition of locomotion via domain-dependent, opposing regulation of Rac1.Scientific reports · 2020Article
- Predominant Distribution of the RNAi Machinery at Apical Adherens Junctions in Colonic Epithelia Is Disrupted in Cancer.International journal of molecular sciences · 2020Article
- Close encounters of the RNAi kind: the silencing life of the adherens junctions.Current opinion in cell biology · 2018Review
- Cadherins: cellular adhesive molecules serving as signalling mediators.The Journal of physiology · 2018Review
- Understanding the extracellular forces that determine cell fate and maintenance.Development (Cambridge, England) · 2017Review
- A central role for cadherin signaling in cancer.Experimental cell research · 2017Review
- Actomyosin contractility provokes contact inhibition in E-cadherin-ligated keratinocytes.Scientific reports · 2017Article
- Circulating and disseminated tumor cells: diagnostic tools and therapeutic targets in motion.Oncotarget · 2017Review
- Fabrication and surface modification of poly lactic acid (PLA) scaffolds with epidermal growth factor for neural tissue engineering.Biomatter · 2016Article
- Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity.Nature cell biology · 2015Article
- Growth Conditions and Cell Cycle Phase Modulate Phase Transition Temperatures in RBL-2H3 Derived Plasma Membrane Vesicles.PloS one · 2015Article
- Forms, forces, and stem cell fate.Current opinion in cell biology · 2014Review
- Downregulation of GRHL2 inhibits the proliferation of colorectal cancer cells by targeting ZEB1.Cancer biology & therapy · 2014Article
- Contact inhibition of locomotion probabilities drive solitary versus collective cell migration.Journal of the Royal Society, Interface · 2013Article
- Regulation of Stem Cell Fate in a Three-Dimensional Micropatterned Dual-Crosslinked Hydrogel System.Advanced functional materials · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
E-cadherin has been linked to the suppression of tumor growth and the inhibition of cell proliferation in culture. We observed that progressively decreasing the seeding density of normal rat kidney-52E (NRK-52E) or MCF-10A epithelial cells from confluence, indeed, released cells from growth arrest. Unexpectedly, a further decrease in seeding density so that cells were isolated from neighboring cells decreased proliferation. Experiments using microengineered substrates showed that E-cadherin engagement stimulated the peak in proliferation at intermediate seeding densities, and that the proliferation arrest at high densities did not involve E-cadherin, but rather resulted from a crowding-dependent decrease in cell spreading against the underlying substrate. Rac1 activity, which was induced by E-cadherin engagement specifically at intermediate seeding densities, was required for the cadherin-stimulated proliferation, and the control of Rac1 activation by E-cadherin was mediated by p120-catenin. Together, these findings demonstrate a stimulatory role for E-cadherin in proliferative regulation, and identify a simple mechanism by which cell-cell contact may trigger or inhibit epithelial cell proliferation in different settings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.