Evidence map›Paper›PMID 16682465›Full record

ArticleEukaryotic cell2006

Characterization and differential nuclear localization of Nopp140 and a novel Nopp140-like protein in trypanosomes.

S Kelly, W Singleton, B Wickstead, K Ersfeld, K Gull

Abstract read
In one paragraph

Article in Eukaryotic cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Cell biology of the trypanosome genome.Microbiology and molecular biology reviews : MMBR · 2010
    Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

S KellySir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom.
W Singleton
B Wickstead
K Ersfeld
K Gull

Funding

Wellcome Trust
6 · The paper itself

Abstract

Trypanosomatids possess two homologues of Nopp140: a canonical Nopp140 and a Nopp140-like protein (TbNoLP) in which a GAR domain replaces the C-terminal SRP40 domain. Both are phosphorylated and coimmunoprecipitate with RNA polymerase I. Each paralogue has a distinct subnuclear localization, and depletion of TbNoLP produces an enlarged nucleolus in which TbNopp140-containing regions disperse. The restricted occurrence pattern of NoLP proteins reflects an intriguing convergence in evolution, suggestive of a function in nucleoplasmic small nucleolar ribonucleoprotein shuttling.

Indexed as

Amino Acid SequenceAnimalsCell NucleolusCell NucleusMolecular Sequence DataNuclear ProteinsPhosphoproteinsPhosphorylationProtozoan ProteinsRibonucleoproteins, Small NucleolarRNA InterferenceRNA Polymerase ITrypanosoma brucei bruceiNOLC1 protein, humanNuclear ProteinsPhosphoproteinsProtozoan ProteinsRibonucleoproteins, Small NucleolarRNA Polymerase I

Identifiers

PMID16682465
PMCPMC1459678

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.