Evidence map›Paper›PMID 16682464›Full record

ArticleEukaryotic cell2006

Stress by heat shock induces massive down regulation of genes and allows differential allelic expression of the Gal/GalNAc lectin in Entamoeba histolytica.

Christian Weber, Ghislaine Guigon, Christiane Bouchier, Lionel Frangeul, Sandrine Moreira, Odile Sismeiro, Catherine Gouyette, David Mirelman, Jean Yves Coppee, Nancy Guillén

Open access · diamondAbstract read
In one paragraph

Article in Eukaryotic cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 72 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Christian WeberUnité Biologie Cellulaire du Parasitisme, INSERM 786, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris Cedex 15, France.
Ghislaine Guigon
Christiane Bouchier
Lionel Frangeul
Sandrine Moreira
Odile Sismeiro
Catherine Gouyette
David Mirelman
Jean Yves Coppee
Nancy Guillén
Institut Pasteur · FRInserm · FRWeizmann Institute of Science · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gene expression analysis by microarray assay revealed that when exposed to stress, Entamoeba histolytica exhibits a specific heat shock response, together with a dramatic overall reduction in gene transcription as well as differential allelic expression of key genes participating in virulence, such as the galactose/N-acetylgalactosamine (Gal/GalNAc) lectin.

Indexed as

Down-RegulationGene Expression RegulationHeat-Shock ResponseAllelesAnimalsEntamoeba histolyticaGenome, ProtozoanLectinsOligonucleotide Array Sequence AnalysisLectins

Identifiers

PMID16682464
PMCPMC1459685
OpenAlexW2170663825

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.