ArticleEukaryotic cell2006
Role of nitrogen and carbon transport, regulation, and metabolism genes for Saccharomyces cerevisiae survival in vivo.
Article in Eukaryotic cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 61 citations in OpenAlex.
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- Molecular targets for antifungals in amino acid and protein biosynthetic pathways.Amino acids · 2021Review
- The leucine biosynthetic pathway is crucial for adaptation to iron starvation and virulence inVirulence · 2019Article
- Environmental effects on soil microbial nitrogen use efficiency are controlled by allocation of organic nitrogen to microbial growth and regulate gross N mineralization.Soil biology & biochemistry · 2019Article
- Potential targets for the development of new antifungal drugs.The Journal of antibiotics · 2018Review
- Genome-Wide Screen forG3 (Bethesda, Md.) · 2018Article
- Phagosomal Neutralization by the Fungal Pathogen Candida albicans Induces Macrophage Pyroptosis.Infection and immunity · 2017Article
- Two FgLEU2 Genes with Different Roles in Leucine Biosynthesis and Infection-Related Morphogenesis in Fusarium graminearum.PloS one · 2016Article
- Acetohydroxyacid synthase FgIlv2 and FgIlv6 are involved in BCAA biosynthesis, mycelial and conidial morphogenesis, and full virulence in Fusarium graminearum.Scientific reports · 2015Article
- Vibrio vulnificus Secretes an Insulin-degrading Enzyme That Promotes Bacterial Proliferation in Vivo.The Journal of biological chemistry · 2015Article
- Inhibitors of amino acids biosynthesis as antifungal agents.Amino acids · 2015Review
- Involvement of threonine deaminase FgIlv1 in isoleucine biosynthesis and full virulence in Fusarium graminearum.Current genetics · 2015Article
- Opportunistic Strains of Saccharomyces cerevisiae: A Potential Risk Sold in Food Products.Frontiers in microbiology · 2015Review
- Adjustment of microbial nitrogen use efficiency to carbon:nitrogen imbalances regulates soil nitrogen cycling.Nature communications · 2014Article
- Cascades of genetic instability resulting from compromised break-induced replication.PLoS genetics · 2014Article
- Transcriptomics in human blood incubation reveals the importance of oxidative stress response in Saccharomyces cerevisiae clinical strains.BMC genomics · 2012Article
- The Aspergillus fumigatus dihydroxyacid dehydratase Ilv3A/IlvC is required for full virulence.PloS one · 2012Article
- Nitrogen metabolite repression of metabolism and virulence in the human fungal pathogen Cryptococcus neoformans.Genetics · 2011Article
- Expression variability of co-regulated genes differentiates Saccharomyces cerevisiae strains.BMC genomics · 2011Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Saccharomyces cerevisiae is both an emerging opportunistic pathogen and a close relative of pathogenic Candida species. To better understand the ecology of fungal infection, we investigated the importance of pathways involved in uptake, metabolism, and biosynthesis of nitrogen and carbon compounds for survival of a clinical S. cerevisiae strain in a murine host. Potential nitrogen sources in vivo include ammonium, urea, and amino acids, while potential carbon sources include glucose, lactate, pyruvate, and fatty acids. Using mutants unable to either transport or utilize these compounds, we demonstrated that no individual nitrogen source was essential, while glucose was the most significant primary carbon source for yeast survival in vivo. Hydrolysis of the storage carbohydrate glycogen made a slight contribution for in vivo survival compared with a substantial requirement for trehalose hydrolysis. The ability to sense and respond to low glucose concentrations was also important for survival. In contrast, there was little or no requirement in vivo in this assay for any of the nitrogen-sensing pathways, nitrogen catabolite repression, the ammonium- or amino acid-sensing pathways, or general control. By using auxotrophic mutants, we found that some nitrogenous compounds (polyamines, methionine, and lysine) can be acquired from the host, while others (threonine, aromatic amino acids, isoleucine, and valine) must be synthesized by the pathogen. Our studies provide insights into the yeast-host environment interaction and identify potential antifungal drug targets.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.