ArticleEukaryotic cell2006
Evidence of mRNA-mediated intron loss in the human-pathogenic fungus Cryptococcus neoformans.
Article in Eukaryotic cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 54 citations in OpenAlex.
- Trends in the evolution of intronless genes inFrontiers in plant science · 2023Article
- Intron losses and gains in the nematodes.Biology direct · 2022Article
- Analysis of Fungal Genomes Reveals Commonalities of Intron Gain or Loss and Functions in Intron-Poor Species.Molecular biology and evolution · 2021Article
- Differences in Sirtuin Regulation in Response to Calorie Restriction in Cryptococcus neoformans.Journal of fungi (Basel, Switzerland) · 2018Article
- Introns in Cryptococcus.Memorias do Instituto Oswaldo Cruz · 2018Review
- Evaluation of the mechanisms of intron loss and gain in the social amoebae Dictyostelium.BMC evolutionary biology · 2015Article
- Reverse transcriptase and intron number evolution.Stem cell investigation · 2014Article
- Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications.G3 (Bethesda, Md.) · 2013Article
- Frequency of intron loss correlates with processed pseudogene abundance: a novel strategy to test the reverse transcriptase model of intron loss.BMC biology · 2013Article
- Identifying the mechanisms of intron gain: progress and trends.Biology direct · 2012Review
- Origin and evolution of spliceosomal introns.Biology direct · 2012Review
- Intron gains and losses in the evolution of Fusarium and Cryptococcus fungi.Genome biology and evolution · 2012Article
- Fungal-induced cell cycle impairment, chromosome instability and apoptosis via differential activation of NF-κB.PLoS pathogens · 2012Article
- Genome-wide analysis of retrogene polymorphisms in Drosophila melanogaster.Genome research · 2011Article
- Finding single copy genes out of sequenced genomes for multilocus phylogenetics in non-model fungi.PloS one · 2011Article
- Contrasting 5' and 3' evolutionary histories and frequent evolutionary convergence in Meis/hth gene structures.Genome biology and evolution · 2011Article
- DNA double-strand break repair and the evolution of intron density.Trends in genetics : TIG · 2011Article
- Evaluation of models of the mechanisms underlying intron loss and gain in Aspergillus fungi.Journal of molecular evolution · 2010Article
- Analysis of gene evolution and metabolic pathways using the Candida Gene Order Browser.BMC genomics · 2010Article
- Gain and loss of an intron in a protein-coding gene in Archaea: the case of an archaeal RNA pseudouridine synthase gene.BMC evolutionary biology · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Introns are a defining feature of eukaryotic genomes, though the mechanism of intron gain or loss is not well understood. Reverse transcription of mRNA followed by homologous recombination with the genome has been posited as a mechanism of intron loss, though little direct evidence of recent loss events has been described to support this model. We find supporting evidence for an mRNA-mediated mechanism of loss through comparative genome analyses that revealed a recent loss of 10 adjacent introns in a 22-exon gene in the human-pathogenic fungus Cryptococcus neoformans. We surveyed the gene structures of the entire genomes of Cryptococcus gattii, which diverged from the C. neoformans lineage 37 million years ago (Mya), and C. neoformans var. grubii and var. neoformans, which diverged 18 Mya. Our comparison revealed greater than 99.9% intron conservation, with evidence from 20 genes showing evidence of intron loss, but no convincing evidence of intron gain. Our findings confirm that Cryptococcus introns have been quite stable over recent evolutionary time, with occasional mRNA-mediated intron loss events.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.