ArticleGut2006
Pit patterns in rectal mucosa assessed by magnifying colonoscope are predictive of relapse in patients with quiescent ulcerative colitis.
Article in Gut, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Incremental Benefit of Achieving Endoscopic and Histologic Remission in Patients With Ulcerative Colitis: A Systematic Review and Meta-Analysis.Gastroenterology · 2020Pooled it
- Endoscopic scoring indices for evaluation of disease activity in ulcerative colitis.The Cochrane database of systematic reviews · 2018Pooled it
- Histological Disease Activity as a Predictor of Clinical Relapse Among Patients With Ulcerative Colitis: Systematic Review and Meta-Analysis.The American journal of gastroenterology · 2016Pooled it
- AI-based quantification of inflammatory extent for relapse prediction in ulcerative colitis: a prospective cohort study.Journal of Crohn's & colitis · 2026Article
- Clinical usefulness of linked color imaging for evaluation of endoscopic activity and prediction of relapse in ulcerative colitis.International journal of colorectal disease · 2021Article
- Endoscopic and Histologic Predictors of Outcomes in Pediatric Ulcerative Colitis-Frontiers in pediatrics · 2021Review
- Can advanced endoscopic techniques for assessment of mucosal inflammation and healing approximate histology in inflammatory bowel disease?Therapeutic advances in gastroenterology · 2019Article
- Narrow band imaging efficiency in evaluation of mucosal healing/relapse of ulcerative colitis.Endoscopy international open · 2018Article
- Clinical relevance of endoscopic assessment of inflammation in ulcerative colitis: Can endoscopic evaluation predict outcomes?World journal of gastroenterology · 2016Review
- Narrow-band imaging with magnifying endoscopy for Peyer's patches is useful in predicting the recurrence of remissive patients with ulcerative colitis.Intestinal research · 2016Article
- Advanced gastrointestinal endoscopic imaging for inflammatory bowel diseases.World journal of gastroenterology · 2016Review
- Clinical usefulness of endocytoscopy in the remission stage of ulcerative colitis: a pilot study.Journal of gastroenterology · 2015Article
- Differential diagnosis in inflammatory bowel disease colitis: state of the art and future perspectives.World journal of gastroenterology · 2015Review
- Indications, stains and techniques in chromoendoscopy.QJM : monthly journal of the Association of Physicians · 2013Review
- Magnifying Endoscopic Findings Can Predict Clinical Outcome during Long-Term Follow-Up of More Than 12 Months in Patients with Ulcerative Colitis.Gastroenterology research and practice · 2013Article
- Advanced endoscopic imaging for diagnosis of Crohn's disease.Gastroenterology research and practice · 2012Article
- Predictors of aggressive inflammatory bowel disease.Gastroenterology & hepatology · 2011Article
- Novel application of low pH-dependent fluorescent dyes to examine colitis.BMC gastroenterology · 2010Article
- Mucosal vascular pattern in ulcerative colitis: observations using narrow band imaging colonoscopy with special reference to histologic inflammation.International journal of colorectal disease · 2009Article
- Recent advances of endoscopy in inflammatory bowel diseases.Gut and liver · 2007Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRelapse of ulcerative colitis is difficult to predict by routine colonoscopy. A high-resolution video-magnifying colonoscope with chromoscopy enables the observation of colorectal mucosal pit patterns.
aimsTo investigate the association of pit patterns as assessed by magnifying colonoscopy (MCS) with histological inflammation and mucosal chemokine activity in patients with quiescent ulcerative colitis, and to prospectively analyse the prognostic factors that may predict exacerbations.
methodsMCS was performed in 113 patients with ulcerative colitis in remission. Pit patterns in the rectal mucosa were classified into four MCS grades on the basis of size, shape and arrangement. Mucosal interleukin (IL) 8 activity was measured in biopsy specimens of rectal mucosa and the specimens were assessed for histological disease activity. The patients were then followed until relapse or for a maximum of 12 months. Multivariate survival analysis was carried out to determine the independent predictors of clinical relapse.
resultsA positive correlation was identified between MCS grade, histological grade (p = 0.001) and mucosal IL8 activity (p<0.001). Multivariate proportional hazard model analysis showed that MCS grade was a significant predictor of relapse (relative risk 2.06, p = 0.001). Kaplan-Meier estimate of relapse during 12 months of follow-up was found to increase with increasing MCS grade, with values of 0% for grade 1, 21% for grade 2, 43% for grade 3 and 60% for grade 4.
conclusionMCS grading is associated with the degree of histological inflammation and mucosal IL8 activity in patients with quiescent ulcerative colitis, and may predict the probability of subsequent disease relapse in patients with ulcerative colitis in remission.
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