ArticleNeuroscience2006
The dynamic range and domain-specific signals of intracellular calcium in photoreceptors.
Article in Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- Retinal TRP channels: Cell-type-specific regulators of retinal homeostasis and multimodal integration.Progress in retinal and eye research · 2023Review
- Calcium flares and compartmentalization in rod photoreceptors.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Weak endogenous Ca2+ buffering supports sustained synaptic transmission by distinct mechanisms in rod and cone photoreceptors in salamander retina.Physiological reports · 2015Article
- Article
- Role of intracellular calcium stores in hair-cell ribbon synapse.Frontiers in cellular neuroscience · 2014Review
- Presynaptic [Ca(2+)] and GCAPs: aspects on the structure and function of photoreceptor ribbon synapses.Frontiers in molecular neuroscience · 2014Review
- Properties of ribbon and non-ribbon release from rod photoreceptors revealed by visualizing individual synaptic vesicles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Store-operated channels regulate intracellular calcium in mammalian rods.The Journal of physiology · 2012Article
- Light-driven calcium signals in mouse cone photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Calcium stores in vertebrate photoreceptors.Advances in experimental medicine and biology · 2012Review
- Release from the cone ribbon synapse under bright light conditions can be controlled by the opening of only a few Ca(2+) channels.Journal of neurophysiology · 2011Article
- Article
- Location of release sites and calcium-activated chloride channels relative to calcium channels at the photoreceptor ribbon synapse.Journal of neurophysiology · 2011Article
- Intracellular pH modulates inner segment calcium homeostasis in vertebrate photoreceptors.American journal of physiology. Cell physiology · 2011Article
- Calcium regulates vesicle replenishment at the cone ribbon synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Quantitative analysis of synaptic release at the photoreceptor synapse.Biophysical journal · 2010Article
- Glutamate-induced internalization of Ca(v)1.3 L-type Ca(2+) channels protects retinal neurons against excitotoxicity.The Journal of physiology · 2010Article
- Vesicle pool size at the salamander cone ribbon synapse.Journal of neurophysiology · 2010Article
- Calcium homeostasis and cone signaling are regulated by interactions between calcium stores and plasma membrane ion channels.PloS one · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Vertebrate photoreceptors consist of strictly delimited subcellular domains: the outer segment, ellipsoid, cell body and synaptic terminal, each hosting crucial cellular functions, including phototransduction, oxidative metabolism, gene expression and transmitter release. We used optical imaging to explore the spatiotemporal dynamics of Ca(2+) signaling in non-outer segment regions of rods and cones. Sustained depolarization, designed to emulate photoreceptor activation in the darkness, evoked a standing Ca(2+) gradient in tiger salamander photoreceptors with spatially-averaged intracellular Ca(2+) concentration within synaptic terminals of approximately 2 microM and lower (approximately 750 nM) intracellular calcium concentration in the ellipsoid. Measurements from axotomized cell bodies and isolated ellipsoids showed that Ca(2+) enters the two compartments via both local L-type Ca(2+) channels and diffusion. The results from optical imaging studies were supported by immunostaining analysis. L-type voltage-operated Ca(2+) channels and plasma membrane Ca(2+) ATPases were highly expressed in synaptic terminals with progressively lower expression levels in the cell body and ellipsoid. These results show photoreceptor Ca(2+) homeostasis is controlled in a region-specific manner by direct Ca(2+) entry and diffusion as well as Ca(2+) extrusion. Moreover, quantitative measurement of intracellular calcium concentration levels in different photoreceptor compartments indicates that the dynamic range of Ca(2+) signaling in photoreceptors is approximately 40-fold, from approximately 50 nM in the light to approximately 2 microM in darkness.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.