ReviewPflugers Archiv : European journal of physiology2006
From cardiac cation channels to the molecular dissection of the transient receptor potential channel TRPM4.
Review in Pflugers Archiv : European journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 58 citations in OpenAlex.
- New insights into the influence of temperature on axonal transport and function in myelinated regions of Schwann cells.iScience · 2025Review
- Roles of TRPM channels in glioma.Cancer biology & therapy · 2024Review
- Article
- Uncoupling cytosolic calcium from membrane voltage by transient receptor potential melastatin 4 channel (TRPM4) modulation: A novel strategy to treat ventricular arrhythmias.Heart rhythm O2 · 2023Review
- Development and characterization of a monoclonal antibody blocking human TRPM4 channel.Scientific reports · 2021Article
- Upregulation of transient receptor potential melastatin 4 (TRPM4) in ventricular fibroblasts from heart failure patients.Pflugers Archiv : European journal of physiology · 2021Article
- Review
- TRPM4 regulates Akt/GSK3-β activity and enhances β-catenin signaling and cell proliferation in prostate cancer cells.Molecular oncology · 2018Article
- Heterologously-expressed and Liposome-reconstituted Human Transient Receptor Potential Melastatin 4 Channel (TRPM4) is a Functional Tetramer.Scientific reports · 2016Article
- The Ca(2+)-activated cation channel TRPM4 is a negative regulator of angiotensin II-induced cardiac hypertrophy.Basic research in cardiology · 2015Article
- Transient receptor potential (TRP) channels and cardiac fibrosis.Current topics in medicinal chemistry · 2013Review
- Transient receptor potential melastatin 4 and cell death.Pflugers Archiv : European journal of physiology · 2012Review
- Transient receptor potential channel m4 and m5 in magnocellular cells in rat supraoptic and paraventricular nuclei.Journal of neuroendocrinology · 2011Article
- Emerging concepts for the role of TRP channels in the cardiovascular system.The Journal of physiology · 2011Review
- The role of transient receptor potential cation channels in Ca2+ signaling.Cold Spring Harbor perspectives in biology · 2010Article
- Impaired endocytosis of the ion channel TRPM4 is associated with human progressive familial heart block type I.The Journal of clinical investigation · 2009Article
- TRP channels and mechanosensory transduction: insights into the arterial myogenic response.Pflugers Archiv : European journal of physiology · 2008Review
- Regulation of transient receptor potential (TRP) channels by phosphoinositides.Pflugers Archiv : European journal of physiology · 2007Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In 2006, we celebrate not only the milestone paper on the patch-clamp technique but also the publication of the first single-channel measurements in cardiac cells revealing a Ca(2+)-activated, nonselective cation channel. Considerable effort has been undertaken since this time to identify molecular candidates for this class of cation channels that can be found in a variety of tissues. Recent work has shown that this channel is very likely TRPM4, a member of the TRPM ion channel family. The current review links the epochal Colquhoun et al. paper to the detailed molecular knowledge and structure function aspects of this TRP channel. It will be shown that TRPM4 is a Ca(2+)- and voltage-activated channel, which is dramatically modulated by the phospholipid phosphatidyl inositol bisphosphate (PIP(2)) and belongs to the heat-activated thermoTRPs. A functional hallmark of TRPM4, as for several TRP channels, is a dramatic shift of its voltage dependence towards negative, physiologically meaningful potentials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.