ReviewJournal of molecular medicine (Berlin, Germany)2006
The endoproteolytic maturation of progastrin and procholecystokinin.
Review in Journal of molecular medicine (Berlin, Germany), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 55 citations in OpenAlex.
- Cholecystokinin: Clinical aspects of the new biology.Journal of internal medicine · 2025Review
- Gastrin and the Moderate Hypergastrinemias.International journal of molecular sciences · 2021Review
- Cholecystokinin and the hormone concept.Endocrine connections · 2021Review
- Evidence That Calcium Entry Into Calcium-Transporting Dental Enamel Cells Is Regulated by Cholecystokinin, Acetylcholine and ATP.Frontiers in physiology · 2018Article
- Islet Cells Serve as Cells of Origin of Pancreatic Gastrin-Positive Endocrine Tumors.Molecular and cellular biology · 2015Article
- Functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development.PloS one · 2015Article
- Glutaminyl cyclase knock-out mice exhibit slight hypothyroidism but no hypogonadism: implications for enzyme function and drug development.The Journal of biological chemistry · 2011Article
- Therapy for obesity based on gastrointestinal hormones.The review of diabetic studies : RDS · 2011Review
- Juvenile polyposis of the stomach--a novel cause of hypergastrinemia.Nature reviews. Gastroenterology & hepatology · 2010Article
- Cholecystokinin is up-regulated in obese mouse islets and expands beta-cell mass by increasing beta-cell survival.Endocrinology · 2010Article
- Transcriptional orchestration of the regulated secretory pathway in neurons by the bHLH protein DIMM.Current biology : CB · 2010Article
- Macrocyclic chelator-coupled gastrin-based radiopharmaceuticals for targeting of gastrin receptor-expressing tumours.European journal of nuclear medicine and molecular imaging · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The homologous brain-gut propeptides, procholecystokinin (proCCK) and progastrin, both undergo extensive posttranslational maturation in specific neuroendocrine cells. The process comprises multiple endoproteolytic cleavages at mono- and dibasic sites, in addition to exoproteolytic trimmings and amino acid derivatizations. Knockout of prohormone convertases (PCs) in mice and studies in cell lines indicate that PC1, PC2 and, to a minor extent, PC5, are responsible for most of the endoproteolytic cleavages of both prohormones. Progastrin in antral G-cells is cleaved by PC1 at two di-Arg sites, R36R37 and R73R74, whereas, PC2 only cleaves at the single di-Lys site, K53K54. Pituitary corticotrophs and intestinal TG-cells, both of which express gastrin, do not cleave K53K54 due to lack of PC2. In proCCK five monobasic (R25, R44, R50, K61 and R75) as well as a single dibasic site (R85R86) can all be cleaved by both PC1 and PC2. But the cleavage differs in a cell-specific manner in that PC1 is responsible for the entire endoproteolytic cleavage in intestinal endocrine I-cells, except for perhaps the K61 site. In contrast PC2 is responsible for most endoproteolysis of proCCK in the cerebral CCK-neurons, which do not express PC1 in significant amounts. Moreover, PC5 appears to contribute to a minor extent to the neuronal proCCK and to the antral progastrin processing. This review emphasizes that prohormone convertases play a decisive but substrate and cell-specific role in the biosynthetic maturation of gastrin and CCK.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.