ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2006
Superoxide dismutase 1 modulates expression of transferrin receptor.
Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02164253 (Feasibility and Safety Pilot Therapeutic Study of the Iron Chelator Deferiprone in Amyotrophic Lateral Sclerosis), which is not on this map. Cited by 16 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Feasibility and Safety Pilot Therapeutic Study of the Iron Chelator Deferiprone in Amyotrophic Lateral Sclerosis
Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
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- Taking Advantages of Blood-Brain or Spinal Cord Barrier Alterations or Restoring Them to Optimize Therapy in ALS?Journal of personalized medicine · 2022Review
- hmSOD1 gene mutation-induced disturbance in iron metabolism is mediated by impairment of Akt signalling pathway.Journal of cachexia, sarcopenia and muscle · 2018Article
- A Summary of New Findings on the Biological Effects of Selenium in Selected Animal Species-A Critical Review.International journal of molecular sciences · 2017Review
- Mice Overexpressing Both Non-Mutated Human SOD1 and Mutated SOD1(G93A) Genes: A Competent Experimental Model for Studying Iron Metabolism in Amyotrophic Lateral Sclerosis.Frontiers in molecular neuroscience · 2015Article
- Shared mechanisms of neurodegeneration in Alzheimer's disease and Parkinson's disease.BioMed research international · 2014Review
- Dysregulation of iron metabolism in Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.Advances in pharmacological sciences · 2011Article
- Iron insufficiency compromises motor neurons and their mitochondrial function in Irp2-null mice.PloS one · 2011Article
- Recent advances in amyotrophic lateral sclerosis research: perspectives for personalized clinical application.The EPMA journal · 2010Article
- Flightless flies: Drosophila models of neuromuscular disease.Annals of the New York Academy of Sciences · 2010Review
- Catalytic activities of dismution reactions of Cu(bpy)Br(2) compound and its derivatives as SOD mimics: a theoretical study.Journal of molecular modeling · 2009Article
- Dysregulation of iron homeostasis in the CNS contributes to disease progression in a mouse model of amyotrophic lateral sclerosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Increased serum ferritin levels in amyotrophic lateral sclerosis (ALS) patients.Journal of neurology · 2008Article
- Serum ferritin and metal levels as risk factors for amyotrophic lateral sclerosis.The open neurology journal · 2008Article
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Authors and funding
14 authors at 6 institutions in 3 countries.
Funding
Abstract
Copper-zinc superoxide dismutase (SOD1) plays a protective role against the toxicity of superoxide, and studies in Saccharomyces cerevisiae and in Drosophila have suggested an additional role for SOD1 in iron metabolism. We have studied the effect of the modulation of SOD1 levels on iron metabolism in a cultured human glial cell line and in a mouse motoneuronal cell line. We observed that levels of the transferrin receptor and the iron regulatory protein 1 were modulated in response to altered intracellular levels of superoxide dismutase activity, carried either by wild-type SOD1 or by an SOD-active amyotrophic lateral sclerosis (ALS) mutant enzyme, G93A-SOD1, but not by a superoxide dismutase inactive ALS mutant, H46R-SOD1. Ferritin expression was also increased by wild-type SOD1 overexpression, but not by mutant SOD1s. We propose that changes in superoxide levels due to alteration of SOD1 activity affect iron metabolism in glial and neuronal cells from higher eukaryotes and that this may be relevant to diseases of the nervous system.
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Registered trials
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