ArticleJournal of molecular neuroscience : MN2006
Math1 target genes are enriched with evolutionarily conserved clustered E-box binding sites.
Article in Journal of molecular neuroscience : MN, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- CASZ1 regulates the maturation of outer hair cells and is required for hearing in mice.iScience · 2026Article
- Article
- The Promoter and Multiple Enhancers of the pou4f3 Gene Regulate Expression in Inner Ear Hair Cells.Molecular neurobiology · 2017Article
- Atoh1 as a Coordinator of Sensory Hair Cell Development and Regeneration in the Cochlea.Chonnam medical journal · 2017Article
- Dual role for Sox2 in specification of sensory competence and regulation of Atoh1 function.Developmental neurobiology · 2017Article
- Inner ear barriers to nanomedicine-augmented drug delivery and imaging.Journal of otology · 2016Review
- The Role of Atonal Factors in Mechanosensory Cell Specification and Function.Molecular neurobiology · 2015Article
- Characterization of the transcriptome of nascent hair cells and identification of direct targets of the Atoh1 transcription factor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Orphan nuclear receptor NR2F6 acts as an essential gatekeeper of Th17 CD4+ T cell effector functions.Cell communication and signaling : CCS · 2014Review
- Bicistronic gene transfer tools for delivery of miRNAs and protein coding sequences.International journal of molecular sciences · 2013Article
- TFE2 and GATA3 enhance induction of POU4F3 and myosin VIIa positive cells in nonsensory cochlear epithelium by ATOH1.Developmental biology · 2012Article
- Regulation of POU4F3 gene expression in hair cells by 5' DNA in mice.Neuroscience · 2011Article
- In vivo neuronal subtype-specific targets of Atoh1 (Math1) in dorsal spinal cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- In vivo Atoh1 targetome reveals how a proneural transcription factor regulates cerebellar development.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- TCF4, schizophrenia, and Pitt-Hopkins Syndrome.Schizophrenia bulletin · 2010Article
- Deletion of Atoh1 disrupts Sonic Hedgehog signaling in the developing cerebellum and prevents medulloblastoma.Science (New York, N.Y.) · 2009Article
- Little but loud: small RNAs have a resounding affect on ear development.Brain research · 2009Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The basic helix-loop-helix (bHLH) transcription factor Math1 and its orthologs are fundamental for proper development of various neuronal subpopulations, such as cerebellar granule cells, D1 interneurons in the spinal cord, and inner ear hair cells. Although crucial for neurogenesis, the mechanisms by which Math1 specifically recognizes its direct targets are not fully understood. To search for direct and indirect target genes and signaling pathways controlled by Math1, we analyzed the effect of Math1 knockout on the expression profile of multiple genes in the embryonic cerebellum. Eighteen differentially expressed transcripts were identified and found to belong to a few developmentally-related functional groups, such as transcriptional regulation, proliferation, organogenesis, signal transduction, and apoptosis. Importantly, genomic analysis of E-box motifs has identified a significant enrichment and clustering of MATH1-binding E-boxes only in a subset of differentially expressed genes (Nr2f6, Hras1, and Hes5) in both mouse and man. Moreover, Math1 was shown by chromatin immunoprecipitation (ChIP) to bind, and by a luciferase reporter assay to activate transcription, of an upstream genomic fragment of Nr2f6. Taken together, we propose that when putative direct targets of Math1 are being selected for detailed studies on DNA microarray hybridization, the enrichment and clustering of binding E-boxes in multiple species may be helpful criteria. Our findings may be useful to the study of other bHLH transcription factors, many of which control the development of the nervous system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.