ArticleThe Plant cell2006
GLABROUS INFLORESCENCE STEMS modulates the regulation by gibberellins of epidermal differentiation and shoot maturation in Arabidopsis.
Article in The Plant cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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Who cites it
67 citing papers in PubMed, 162 citations in OpenAlex.
- Coordinated MBW, GIS, and RSL Regulatory Networks in Plant Epidermal Patterning Under Environmental Cues.International journal of molecular sciences · 2026Review
- The C2H2-type zinc finger protein SlHair5 acts as a regulatory node coordinating trichome development and leaf morphogenesis in tomato.Plant cell reports · 2026Article
- Multifaceted Roles of SPL9 in Plant Growth, Development, and Stress Responses: A Review.Plants (Basel, Switzerland) · 2026Review
- Structural innovation under environmental pressure: the evolutionary origins and regulatory mechanisms of thorns.Forestry research · 2026Review
- NtispH as a key regulator of glandular trichome development and terpenoid metabolism in tobacco (Nicotiana tabacum).Journal of plant research · 2026Article
- Article
- C2H2 Zinc Finger Proteins GIS2 and ZFP8 Regulate Trichome Development via Hormone Signaling in Arabidopsis.International journal of molecular sciences · 2025Article
- SlH3 and SlH4 promote multicellular trichome formation and elongation by upregulating woolly in tomato.Horticulture research · 2025Article
- Unraveling the lncRNA-miRNA-mRNA Regulatory Network Involved in Poplar Coma Development through High-Throughput Sequencing.International journal of molecular sciences · 2024Article
- Article
- Genetic basis of nectar guide trichome variation between bumblebee- and self-pollinated monkeyflowers (Mimulus): role of the MIXTA-like gene GUIDELESS.BMC plant biology · 2024Article
- Exogenous 6-BA enhances salt tolerance of Limonium bicolor by increasing the number of salt glands.Plant cell reports · 2023Article
- Genome-wide identification and expression analysis of the GASA gene family in Chinese cabbage (Brassica rapa L. ssp. pekinensis).BMC genomics · 2023Article
- TOE1/TOE2 Interacting with GIS to Control Trichome Development inInternational journal of molecular sciences · 2023Article
- SlZF3 regulates tomato plant height by directly repressingHorticulture research · 2023Article
- Loss function ofFrontiers in plant science · 2023Article
- QTL mapping and stability analysis of trichome density in zucchini (Frontiers in plant science · 2023Article
- Multi-Dimensional Molecular Regulation of Trichome Development inFrontiers in plant science · 2022Review
- Rose without prickle: genomic insights linked to moisture adaptation.National science review · 2021Article
- Involvement of ABA ResponsiveInternational journal of molecular sciences · 2021Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As a plant shoot matures, it transitions through a series of growth phases in which successive aerial organs undergo distinct developmental changes. This process of phase change is known to be influenced by gibberellins (GAs). We report the identification of a putative transcription factor, GLABROUS INFLORESCENCE STEMS (GIS), which regulates aspects of shoot maturation in Arabidopsis thaliana. GIS loss-of-function mutations affect the epidermal differentiation of inflorescence organs, causing a premature decrease in trichome production on successive leaves, stem internodes, and branches. Overexpression has the opposite effect on trichome initiation and causes other heterochronic phenotypes, affecting flowering and juvenile-adult leaf transition and inducing the formation of rosette leaves on inflorescence stems. Genetic and gene expression analyses suggest that GIS acts in a GA-responsive pathway upstream of the trichome initiation regulator GLABROUS1 (GL1) and downstream of the GA signaling repressor SPINDLY (SPY). GIS mediates the induction of GL1 expression by GA in inflorescence organs and is antagonized in its action by the DELLA repressor GAI. The implication of GIS in the broader regulation of phase change is further suggested by the delay in flowering caused by GIS loss of function in the spy background. The discovery of GIS reveals a novel mechanism in the control of shoot maturation, through which GAs regulate cellular differentiation in plants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.