ReviewJournal of clinical pathology2006
Dynamic behavioural interpretation of cervical intraepithelial neoplasia with molecular biomarkers.
Review in Journal of clinical pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed.
- TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia (TOPIC trial): study protocol for a randomized controlled trial.BMC cancer · 2016Trial
- The role of HR-HPV integration in the progression of premalignant lesions into different cancer types.Heliyon · 2024Review
- Association between p16/Ki-67 dual stain cytology results prior to and 6 months after LLETZ treatment for CIN and the follow-up regimen three years after treatment: a retrospective cohort study.Archives of gynecology and obstetrics · 2024Article
- Impact of CD44 genetic variants on clinicopathological characteristics of uterine cervical cancer patients.International journal of medical sciences · 2024Article
- p16Clinical and translational medicine · 2023Article
- The impact of Aurora kinase A genetic polymorphisms on cervical cancer progression and clinicopathologic characteristics.International journal of medical sciences · 2021Observational
- Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice.Cancer science · 2020Article
- Investigation of metastasis-associated in colon cancer-1 genetic variants in the development and clinicopathologcial characteristics of uterine cervical cancer in Taiwanese women.International journal of medical sciences · 2020Article
- Toward development of a large field-of-view cancer screening patch (CASP) to detect cervical intraepithelial neoplasia.Biomedical optics express · 2019Article
- Role ofBMJ open · 2019Observational
- On-chip immunofluorescence analysis of single cervical cells using an electroactive microwell array with barrier for cervical screening.Biomicrofluidics · 2019Article
- The clinicopathological characteristic associations of long non-coding RNA gene H19 polymorphisms with uterine cervical cancer.Journal of Cancer · 2019Article
- Involvement of endothelial nitric oxide synthase gene variants in the aggressiveness of uterine cervical cancer.Journal of Cancer · 2019Article
- HPV E4 expression and DNA hypermethylation of CADM1, MAL, and miR124-2 genes in cervical cancer and precursor lesions.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2018Article
- Three-tiered score for Ki-67 and p16Journal of clinical pathology · 2018Article
- Single nucleotide polymorphisms and haplotypes of carbonic anhydrase 9 can predict invasive squamous cell carcinoma of uterine cervix.International journal of medical sciences · 2018Article
- Relationship of genetic variant distributions of WW domain-containing oxidoreductase gene with uterine cervical cancer.International journal of medical sciences · 2018Article
- Significant association of long non-coding RNAs HOTAIR genetic polymorphisms with cancer recurrence and patient survival in patients with uterine cervical cancer.International journal of medical sciences · 2018Article
- Impact of the Receptor for Advanced Glycation End Products Genetic Polymorphisms on the Progression in Uterine Cervical Cancer.Journal of Cancer · 2018Article
- Impact of microRNA-34a and polymorphism of its target geneOncotarget · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The microscopic phenotype of cervical intraepithelial neoplasia (CIN) reflects a fine balance between factors that promote or reduce CIN development. A shortcoming of the current grading system is its reliance on static morphology and microscopic haematoxylin-eosin features of the epithelium alone. In reality, CIN is a dynamic process, and the epithelium may exhibit differing results over time. Functional biomarkers p16, Ki-67, p53, retinoblastoma protein cytokeratin (CK)14 and CK13, help in the assessment of an individual CIN's lesion's potential for progression and regression. The aggregate information provided by these biomarkers exceeds the value of the classic grading system. Consequently, many more CINs that will either regress or progress can be accurately identified. These findings agree with known molecular interactions between HPV and the host. For accurate interpretation of a CIN, it is essential that these biomarkers be determined quantitatively and separately in the superficial, middle and deep layers of the epithelium. Such geography-specific epithelial evaluations of quantitative biomarkers emphasise the dynamic nature of a particular CIN lesion, thereby changing the art of static morphology grading into dynamic interpretation of the diseased tissue, with a strong prognostic effect.
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Registered trials
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