Evidence map›Paper›PMID 16678566›Full record

ArticleGastroenterology2006

Childhood functional gastrointestinal disorders: child/adolescent.

Andrée Rasquin, Carlo Di Lorenzo, David Forbes, Ernesto Guiraldes, Jeffrey S Hyams, Annamaria Staiano, Lynn S Walker

10 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 10 registered trials, which are not on this map. Cited by 536 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
536citing papers in PubMed, 19 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00677976 completednot on this mapstarted 2007, after this paper: background citation

Use of Functional Magnetic Resonance Imaging (fMRI) to Study Brain Activation Following Rectal Stimulation in Children With Irritable Bowel Syndrome

TypeobservationalSponsorMedical College of WisconsinRan2007 to 2013Enrolled17ConditionsIrritable Bowel Syndrome
NCT02340312 completednot on this mapstarted 2015, after this paper: background citation

Evaluation of the Duodenal Microbiome in Pediatric Functional Dyspepsia

TypeobservationalSponsorChildren's Mercy Hospital Kansas CityRan2015 to 2018Enrolled40ConditionsFunctional DyspepsiaArmsEGD, Collection of Stool Specimens
NCT02565355 nacompletednot on this mapstarted 2015, after this paper: background citation

Randomized Controlled Trial of Food Elimination Based on IgG Antibodies for Treatment of Functional Gastrointestinal Diseases (FGIDs) in Children

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2015 to 2017Enrolled60ConditionsFunctional Gastrointestinal Disorders, Functional Abdominal Pain Syndrome, Abdominal Pain (AP)ArmsDietary Exclusion, Standard Treatment
NCT03177434 phase4unknown statusnot on this mapstarted 2016, after this paper: background citation

Multicenter Study Evaluating the Efficacy of Dicopeg Junior in Comparison With Lactulose for the Treatment of Functional Constipation in Children Aged 6 Months to 6 Years. A Prospective, Randomized Study.

TypeinterventionalSponsorChildren's Memorial Health Institute, PolandRan2016 to 2018Enrolled102ConditionsConstipationArmspolyethylene glycols (PEG) 3350, Lactulose Oral Product
NCT04273295 nacompletednot on this mapstarted 2019, after this paper: background citation

Massage With Senna-based Laxatives Versus Senna-based Laxatives in Managing Overflow Retentive Stool Incontinence in Pediatrics

TypeinterventionalSponsorSouth Valley UniversityRan2019 to 2019Enrolled50ConditionsMassageArmsAbdominal massage
NCT04614935 nacompletednot on this mapstarted 2020, after this paper: background citation

Adherence and Outcomes in Functional Constipation With a Constipation Action Plan

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2020 to 2022Enrolled38ConditionsAdherence, Medication, Functional Constipation, Pediatric ALL, Survey, Family LifeArmsAction Plan
NCT05209646 nacompletednot on this mapstarted 2022, after this paper: background citation

Bee Honey as a Therapeutic Modality for Children With Functional Dyspepsia

TypeinterventionalSponsorAin Shams UniversityRan2022 to 2022Enrolled60ConditionsFunctional Gastrointestinal DisordersArmsBee honey
NCT05795049 active not recruitingnot on this mapstarted 2024, after this paper: background citation

Genetic Carbohydrate Maldigestion as a Model to Study Food Hypersensitivity Mechanism and Guide Personalised Treatment Using a Non-invasive Multiparametric Test (Work Package 1)

TypeobservationalSponsorNottingham University Hospitals NHS TrustRan2024 to 2026Enrolled2,000ConditionsIrritable Bowel Syndrome (IBS), Sucrase Isomaltase DeficiencyArmsStool and saliva sample collection, Questionnaire completion
NCT05802732 unknown statusnot on this mapstarted 2023, after this paper: background citation

Diagnostic Accuracy Of Stool Antigen In Diagnosis Of Helicobacter Pylori Infection In Children

TypeobservationalSponsorAssiut UniversityRan2023 to 2024Enrolled63ConditionsHelicobacter Pylori InfectionArmsStool Antigen test
NCT06349031 phase4unknown statusnot on this mapstarted 2024, after this paper: background citation

Comparison of Efficacy & Tolerability Of Polyethylene Glycol 4000 Versus Polyethylene Glycol 3350+ Electrolytes For Fecal Disimpaction in Pediatric Functional Constipation: A Double-Blind Randomized Controlled Trial

TypeinterventionalSponsorInstitute of Medical Sciences and SUM HospitalRan2024 to 2024Enrolled100ConditionsFunctional Constipation, Fecal Impaction, Constipation - Functional, Constipation Chronic IdiopathicArmsAdministration of Polyethylene Glycol (PEG) 4000 as per treatment allocation to participants, Administration of Polyethylene Glycol (PEG) 3350 + Electrolyte as per treatment allocation to participants
3 · Its place in the literature

Who cites it

536 citing papers in PubMed, 19 syntheses or guidelines pooled it.

  1. Pooled it
  2. Efficacy and Safety ofNutrients · 2026
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pharmacological treatment of gastro-oesophageal reflux in children.The Cochrane database of systematic reviews · 2023
    Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Probiotics for treatment of chronic constipation in children.The Cochrane database of systematic reviews · 2022
    Pooled it
  16. Pooled it
  17. Pooled it
  18. Pooled it
  19. Pooled it
  20. Effectiveness of hypnotherapy for paediatric abdominal pain in primary care: a randomised controlled trial.The British journal of general practice : the journal of the Royal College of General Practitioners · 2026
    Trial

476 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Andrée RasquinDivision of Pediatric Gastroenterology and Nutrition, CHU Ste Justine, University of Montreal, Montreal, Quebec, Canada. a.rasquin@umontreal.ca
Carlo Di Lorenzo
David Forbes
Ernesto Guiraldes
Jeffrey S Hyams
Annamaria Staiano
Lynn S Walker

Funding

PATHWAYS TO NEW BIOMARKERS IN RECURRENT ABDOMINAL PAIN IN CHILDRENR01NR013497 · NINR · BAYLOR COLLEGE OF MEDICINE · PI SAVIDGE, TOR C. · 2012 to 2024
$4.7M
NINR NIH HHS R01 NR013497
6 · The paper itself

Abstract

The Rome II pediatric criteria for functional gastrointestinal disorders (FGIDs) were defined in 1999 to be used as diagnostic tools and to advance empirical research. In this document, the Rome III Committee aimed to update and revise the pediatric criteria. The decision-making process to define Rome III criteria for children aged 4-18 years consisted of arriving at a consensus based on clinical experience and review of the literature. Whenever possible, changes in the criteria were evidence based. Otherwise, clinical experience was used when deemed necessary. Few publications addressing Rome II criteria were available to guide the committee. The clinical entities addressed include (1) cyclic vomiting syndrome, rumination, and aerophagia; 2) abdominal pain-related FGIDs including functional dyspepsia, irritable bowel syndrome, abdominal migraine, and functional abdominal pain; and (3) functional constipation and non-retentive fecal incontinence. Adolescent rumination and functional constipation are newly defined for this age group, and the previously designated functional fecal retention is now included in functional constipation. Other notable changes from Rome II to Rome III criteria include the decrease from 3 to 2 months in required symptom duration for noncyclic disorders and the modification of the criteria for functional abdominal pain. The Rome III child and adolescent criteria represent an evolution from Rome II and should prove useful for both clinicians and researchers dealing with childhood FGIDs. The future availability of additional evidence-based data will likely continue to modify pediatric criteria for FGIDs.

Indexed as

Abdominal PainAdolescentChildConstipationFecal IncontinenceHumansVomiting

Identifiers

PMID16678566
PMCPMC7104693

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

and 4 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.