ArticleNeuropeptides2006
Cocaine treatment alters oxytocin receptor binding but not mRNA production in postpartum rat dams.
Article in Neuropeptides, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Coordination of social behaviors by the bed nucleus of the stria terminalis.The European journal of neuroscience · 2022Pooled it
- Oxytocin in Schizophrenia: Pathophysiology and Implications for Future Treatment.International journal of molecular sciences · 2021Review
- The role of oxytocin in regulation of appetitive behaviour, body weight and glucose homeostasis.Journal of neuroendocrinology · 2020Review
- Romantic Love vs. Drug Addiction May Inspire a New Treatment for Addiction.Frontiers in psychology · 2016Review
- Central oxytocin and food intake: focus on macronutrient-driven reward.Frontiers in endocrinology · 2015Review
- Prenatal and gestational cocaine exposure: Effects on the oxytocin system and social behavior with implications for addiction.Pharmacology, biochemistry, and behavior · 2014Review
- Plasma oxytocin concentrations are lower in depressed vs. healthy control women and are independent of cortisol.Journal of psychiatric research · 2014Article
- Effects of cocaine on maternal behavior and neurochemistry.Current neuropharmacology · 2012Article
- Cocaine alters dendritic spine density in cortical and subcortical brain regions of the postpartum and virgin female rat.Synapse (New York, N.Y.) · 2011Article
- Oxytocin, dopamine, and the amygdala: a neurofunctional model of social cognitive deficits in schizophrenia.Schizophrenia bulletin · 2011Article
- Social behavior of offspring following prenatal cocaine exposure in rodents: a comparison with prenatal alcohol.Frontiers in psychiatry · 2011Article
- Combined norepinephrine/serotonergic reuptake inhibition: effects on maternal behavior, aggression, and oxytocin in the rat.Frontiers in psychiatry · 2011Article
- Disruption of maternal parenting circuitry by addictive process: rewiring of reward and stress systems.Frontiers in psychiatry · 2011Article
- Effects of chronic and intermittent cocaine treatment on dominance, aggression, and oxytocin levels in post-lactational rats.Psychopharmacology · 2010Article
- Effect of cocaine sensitization prior to pregnancy on maternal care and aggression in the rat.Psychopharmacology · 2010Article
- Intergenerational effects of cocaine on maternal aggressive behavior and brain oxytocin in rat dams.Stress (Amsterdam, Netherlands) · 2008Article
- From ultrasocial to antisocial: a role for oxytocin in the acute reinforcing effects and long-term adverse consequences of drug use?British journal of pharmacology · 2008Review
- Simultaneous prenatal ethanol and nicotine exposure affect ethanol consumption, ethanol preference and oxytocin receptor binding in adolescent and adult rats.Neurotoxicology and teratologyArticle
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Gestational cocaine treatment in rat dams results in decreased oxytocin (OT) levels, up-regulated oxytocin receptor (OTR) binding density and decreased receptor affinity in the whole amygdala, all concomitant with a significant increase in maternal aggression on postpartum day six. Rat dams with no gestational drug treatment that received an infusion of an OT antagonist directly into the central nucleus of the amygdala (CeA) exhibited similarly high levels of maternal aggression towards intruders. Additionally, studies indicate that decreased OT release from the hypothalamic division of the paraventricular nucleus (PVN) is coincident with heightened maternal aggression in rats. Thus, it appears that cocaine-induced alterations in OT system dynamics (levels, receptors, production, and/or release) may mediate heightened maternal aggression following cocaine treatment, but the exact mechanisms through which cocaine impacts the OT system have not yet been determined. Based on previous studies, we hypothesized that two likely mechanisms of cocaine's action would be, increased OTR binding specifically in the CeA, and decreased OT mRNA production in the PVN. Autoradiography and in situ hybridization assays were performed on targeted nuclei in brain regions of rat dams on postpartum day six, following gestational treatment twice daily with cocaine (15 mg/kg) or normal saline (1 ml/kg). We now report cocaine-induced reductions in OTR binding density in the ventromedial hypothalamus (VMH) and bed nucleus of the stria terminalis (BNST), but not the CeA. There was no significant change in OT mRNA production in the PVN following cocaine treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.