ArticleThe Journal of physiology2006
Muscle denervation promotes opening of the permeability transition pore and increases the expression of cyclophilin D.
Article in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 68 citations in OpenAlex.
- Downhill running induced mitophagy in rat soleus muscle via the AMPK pathway.Journal of physiology and biochemistry · 2025Article
- Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions.Cell death and differentiation · 2023Review
- Mitochondrial Dysfunction in Intensive Care Unit-Acquired Weakness and Critical Illness Myopathy: A Narrative Review.International journal of molecular sciences · 2023Review
- Impact of aging and oxidative stress on specific components of excitation contraction coupling in regulating force generation.Science advances · 2022Article
- Anti-apoptotic effect of adipose tissue-derived stromal vascular fraction in denervated rat muscle.Stem cell research & therapy · 2021Article
- Physiological CaFrontiers in physiology · 2020Review
- Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching.Journal of cachexia, sarcopenia and muscle · 2019Article
- Mitochondrial dysfunction induces muscle atrophy during prolonged inactivity: A review of the causes and effects.Archives of biochemistry and biophysics · 2019Review
- Absence of physiological CaSkeletal muscle · 2017Article
- Denervation drives mitochondrial dysfunction in skeletal muscle of octogenarians.The Journal of physiology · 2016Article
- The Mitochondrial Permeability Transition Pore Regulator Cyclophilin D Exhibits Tissue-Specific Control of Metabolic Homeostasis.PloS one · 2016Article
- Exercise-Induced Changes in Caveolin-1, Depletion of Mitochondrial Cholesterol, and the Inhibition of Mitochondrial Swelling in Rat Skeletal Muscle but Not in the Liver.Oxidative medicine and cellular longevity · 2016Article
- Recent advances in mitochondrial turnover during chronic muscle disuse.Integrative medicine research · 2014Review
- Article
- Mitochondrial involvement and impact in aging skeletal muscle.Frontiers in aging neuroscience · 2014Review
- Role of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) in denervation-induced atrophy in aged muscle: facts and hypotheses.Longevity & healthspan · 2013Article
- Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy.Biological chemistry · 2013Review
- The mitochondrial permeability transition pore: a mystery solved?Frontiers in physiology · 2013Article
- Peroxisome proliferator-activated receptor γ coactivator1- gene α transfer restores mitochondrial biomass and improves mitochondrial calcium handling in post-necrotic mdx mouse skeletal muscle.The Journal of physiology · 2012Article
- The permeability transition pore as a Ca(2+) release channel: new answers to an old question.Cell calcium · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Loss of neural input to skeletal muscle fibres induces atrophy and degeneration with evidence of mitochondria-mediated cell death. However, the effect of denervation on the permeability transition pore (PTP), a mitochondrial protein complex implicated in cell death, is uncertain. In the present study, the impact of 21 days of denervation on the sensitivity of the PTP to Ca2+-induced opening was studied in isolated muscle mitochondria. Muscle denervation increased the sensitivity to Ca2+-induced opening of the PTP, as indicated by a significant decrease in calcium retention capacity (CRC: 111 +/- 12 versus 475 +/- 33 nmol (mg protein)(-1) for denervated and sham, respectively). This phenomenon was partly attributable to in vivo mitochondrial and whole muscle Ca2+ overload. Cyclosporin A, which inhibits PTP opening by binding to cyclophilin D (CypD), was significantly more potent in mitochondria from denervated muscle and restored CRC to the level observed in mitochondria from sham-operated muscles. In contrast, the CypD independent inhibitor trifluoperazine was equally effective at inhibiting PTP opening in sham and denervated animals and did not correct the difference in CRC between groups. This phenomenon was associated with a significant increase in the content of the PTP regulating protein CypD relative to several mitochondrial marker proteins. Together, these results indicate that Ca2+ overload in vivo and an altered expression of CypD could predispose mitochondria to permeability transition in denervated muscles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.