ArticleEnvironmental health perspectives2006
Comparison of oxidative properties, light absorbance, total and elemental mass concentration of ambient PM2.5 collected at 20 European sites.
Article in Environmental health perspectives, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 212 citations in OpenAlex.
- Oxidative Potential Versus Biological Effects: A Review on the Relevance of Cell-Free/Abiotic Assays as Predictors of Toxicity from Airborne Particulate Matter.International journal of molecular sciences · 2019Pooled it
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- Oxidative potential of PMScientific reports · 2025Article
- A Review of Road Traffic-Derived Non-Exhaust Particles: Emissions, Physicochemical Characteristics, Health Risks, and Mitigation Measures.Environmental science & technology · 2022Review
- Effect of polycyclic aromatic hydrocarbons on immunity.Journal of translational autoimmunity · 2022Article
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- Ascorbate oxidation by iron, copper and reactive oxygen species: review, model development, and derivation of key rate constants.Scientific reports · 2021Article
- Cell-based assays that predict in vivo neurotoxicity of urban ambient nano-sized particulate matter.Free radical biology & medicine · 2019Article
- Transcriptomic analysis reveals flavonoid biosynthesis of Syringa oblata Lindl. in response to different light intensity.BMC plant biology · 2019Article
- Summary of the underlying dataset to assist in tracking resilience of rural agricultural communities.Data in brief · 2019Article
- Oxidative Potential of Particles at a Research House: Influencing Factors and Comparison with Outdoor Particles.Building and environment · 2019Article
- Biological and chemical compositions of atmospheric particulate matter during hazardous haze days in Beijing.Environmental science and pollution research international · 2018Article
- Physiochemical characteristics and oxidative potential of ambient air particulate matter (PMJournal of environmental health science & engineering · 2018Article
- Personal Exposure to PMEnvironmental science & technology · 2018Article
- Oxidative potential (OP) and mineralogy of iron ore particulate matter at the Gol-E-Gohar Mining and Industrial Facility (Iran).Environmental geochemistry and health · 2018Article
- Fine Particulate Air Pollution and Adverse Birth Outcomes: Effect Modification by Regional Nonvolatile Oxidative Potential.Environmental health perspectives · 2018Article
- A critical review of assays for hazardous components of air pollution.Free radical biology & medicine · 2018Review
- Interactions of GST Polymorphisms in Air Pollution Exposure and Respiratory Diseases and Allergies.Current allergy and asthma reports · 2016Review
Corrections and comments
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Authors and funding
17 authors at 11 institutions in 9 countries.
Funding
Abstract
objectiveIt has been proposed that the redox activity of particles may represent a major determinant of their toxicity. We measured the in vitro ability of ambient fine particles [particulate matter with aerodynamic diameters<or=2.5 microm (PM2.5)] to form hydroxyl radicals (.OH) in an oxidant environment, as well as to deplete physiologic antioxidants (ascorbic acid, glutathione) in the naturally reducing environment of the respiratory tract lining fluid (RTLF). The objective was to examine how these toxicologically relevant measures were related to other PM characteristics, such as total and elemental mass concentration and light absorbance.
designGravimetric PM2.5 samples (n=716) collected over 1 year from 20 centers participating in the European Community Respiratory Health Survey were available. Light absorbance of these filters was measured with reflectometry. PM suspensions were recovered from filters by vortexing and sonication before dilution to a standard concentration. The oxidative activity of these particle suspensions was then assessed by measuring their ability to generate .OH in the presence of hydrogen peroxide, using electron spin resonance and 5,5-dimethyl-1-pyrroline-N-oxide as spin trap, or by establishing their capacity to deplete antioxidants from a synthetic model of the RTLF. RESULTS AND
conclusionPM oxidative activity varied significantly among European sampling sites. Correlations between oxidative activity and all other characteristics of PM were low, both within centers (temporal correlation) and across communities (annual mean). Thus, no single surrogate measure of PM redox activity could be identified. Because these novel measures are suggested to reflect crucial biologic mechanisms of PM, their use may be pertinent in epidemiologic studies. Therefore, it is important to define the appropriate methods to determine oxidative activity of PM.
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Registered trials
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