SynthesisEnvironmental health perspectives2006
Arsenic exposure and type 2 diabetes: a systematic review of the experimental and epidemiological evidence.
Synthesis in Environmental health perspectives, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
150 citing papers in PubMed, 7 syntheses or guidelines pooled it, 334 citations in OpenAlex.
- Association between DDT or its byproducts and T2DM: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Inorganic arsenic and respiratory health, from early life exposure to sex-specific effects: A systematic review.Environmental research · 2016Pooled it
- Use of Systematic Review and Meta-Analysis in Environmental Health Epidemiology: a Systematic Review and Comparison with Guidelines.Current environmental health reports · 2015Pooled it
- Association of arsenic with adverse pregnancy outcomes/infant mortality: a systematic review and meta-analysis.Environmental health perspectives · 2015Pooled it
- Exposure to organochlorine pollutants and type 2 diabetes: a systematic review and meta-analysis.PloS one · 2014Pooled it
- Environmental chemicals and type 2 diabetes: an updated systematic review of the epidemiologic evidence.Current diabetes reports · 2013Pooled it
- Arsenic exposure and cardiovascular disease: an updated systematic review.Current atherosclerosis reports · 2012Pooled it
- Baseline comorbidities in a skin cancer prevention trial in Bangladesh.European journal of clinical investigation · 2013Trial
- Occupational heavy metal exposure and endocrine-metabolic biomarkers: a retrospective analysis of 34,595 screened individuals in Türkiye.BMC endocrine disorders · 2026Article
- The diabetes exposome: interplay of environmental and genetic determinants in diabetes.Human genomics · 2026Review
- Associations of occupational exposure to multiple heavy metals and metabolic syndrome among metal foundry workers: a cross‑sectional study.BMC endocrine disorders · 2026Article
- Machine learning based identification of key predictors and socioeconomic inequalities in the co-existence of diabetes and hypertension among Bangladeshi adults.Scientific reports · 2026Article
- Soil health to human health: impacts of soil contaminants on cardio-neurological health and clinical outcomes: a narrative review.Frontiers in cardiovascular medicine · 2026Review
- From toxicogenomics data to cumulative assessment groups: a framework for chemical grouping.Archives of toxicology · 2026Article
- Transgenerational diabetogenic effects of preconception exposure to inorganic arsenic in C57BL/6 mice are associated with dysregulation of DNA methylation and gene expression in G1 and G2 offspring.Archives of toxicology · 2025Article
- Endocrine-disrupting chemicals exposure: cardiometabolic health risk in humans.Cardiovascular diabetology · 2025Review
- Environmental Insults to Glucose Metabolism: The Role of Pollutants in Insulin Resistance.International journal of molecular sciences · 2025Review
- Effect of Arsenic Exposure on AS3MT Protein Levels in Serum of Type 2 Diabetic Patients Compared to Non-diabetics.Biological trace element research · 2025Article
- Health risk assessment upon exposure to groundwater arsenic among individuals of different sex and age groups of Vaishali district, Bihar (India).Toxicology reports · 2025Article
- Arsenic speciation analysis in human urine for long term epidemiological studies: The Multi-Ethnic Study of Atherosclerosis (MESA).Environmental research · 2024Article
90 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Chronic arsenic exposure has been suggested to contribute to diabetes development. We performed a systematic review of the experimental and epidemiologic evidence on the association of arsenic and type 2 diabetes. We identified 19 in vitro studies of arsenic and glucose metabolism. Five studies reported that arsenic interfered with transcription factors involved in insulin-related gene expression: upstream factor 1 in pancreatic beta-cells and peroxisome proliferative-activated receptor gamma in preadipocytes. Other in vitro studies assessed the effect of arsenic on glucose uptake, typically using very high concentrations of arsenite or arsenate. These studies provide limited insight on potential mechanisms. We identified 10 in vivo studies in animals. These studies showed inconsistent effects of arsenic on glucose metabolism. Finally, we identified 19 epidemiologic studies (6 in high-arsenic areas in Taiwan and Bangladesh, 9 in occupational populations, and 4 in other populations). In studies from Taiwan and Bangladesh, the pooled relative risk estimate for diabetes comparing extreme arsenic exposure categories was 2.52 (95% confidence interval, 1.69-3.75), although methodologic problems limit the interpretation of the association. The evidence from occupational studies and from general populations other than Taiwan or Bangladesh was inconsistent. In summary, the current available evidence is inadequate to establish a causal role of arsenic in diabetes. Because arsenic exposure is widespread and diabetes prevalence is reaching epidemic proportions, experimental studies using arsenic concentrations relevant to human exposure and prospective epidemiologic studies measuring arsenic biomarkers and appropriately assessing diabetes should be a research priority.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.