ArticleBMC genomics2006
Reduction/oxidation-phosphorylation control of DNA binding in the bZIP dimerization network.
Article in BMC genomics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- An interplay between bZIP16, bZIP68, and GBF1 regulates nuclear photosynthetic genes during photomorphogenesis in Arabidopsis.The New phytologist · 2023Article
- Therapeutic Potential of Perillaldehyde in Ameliorating Vulvovaginal Candidiasis by Reducing Vaginal Oxidative Stress and Apoptosis.Antioxidants (Basel, Switzerland) · 2022Article
- Targeted manipulation of bZIP53 DNA-binding properties influences Arabidopsis metabolism and growth.Journal of experimental botany · 2019Article
- Insights from the crystal structure of the chicken CREB3 bZIP suggest that members of the CREB3 subfamily transcription factors may be activated in response to oxidative stress.Protein science : a publication of the Protein Society · 2019Article
- Engineering of the Filamentous FungusFrontiers in microbiology · 2018Review
- Activator Protein-1: redox switch controlling structure and DNA-binding.Nucleic acids research · 2017Article
- Transcriptome analysis of the spalax hypoxia survival response includes suppression of apoptosis and tight control of angiogenesis.BMC genomics · 2012Article
- Redox-mediated mechanisms regulate DNA binding activity of the G-group of basic region leucine zipper (bZIP) transcription factors in Arabidopsis.The Journal of biological chemistry · 2012Article
- Elucidation of functional markers from Aspergillus nidulans developmental regulator FlbB and their phylogenetic distribution.PloS one · 2011Article
- Batf coordinates multiple aspects of B and T cell function required for normal antibody responses.The Journal of experimental medicine · 2010Article
- Experimental determination of the evolvability of a transcription factor.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Reconstruction of ancestral protein interaction networks for the bZIP transcription factors.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- An exploration of alternative visualisations of the basic helix-loop-helix protein interaction network.BMC bioinformatics · 2007Article
- A protein interaction atlas for the nuclear receptors: properties and quality of a hub-based dimerisation network.BMC systems biology · 2007Article
- Cis-regulatory control of the nodal gene, initiator of the sea urchin oral ectoderm gene network.Developmental biology · 2007Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundbZIPs are transcription factors that are found throughout the eukarya from fungi to flowering plants and mammals. They contain highly conserved basic region (BR) and leucine zipper (LZ) domains and often function as environmental sensors. Specifically, bZIPs frequently have a role in mediating the response to oxidative stress, a crucial environmental signal that needs to be transduced to the gene regulatory network.
resultsBased on sequence comparisons and experimental data on a number of important bZIP transcription factors, we predict which bZIPs are under redox control and which are regulated via protein phosphorylation. By integrating genomic, phylogenetic and functional data from the literature, we then propose a link between oxidative stress and the choice of interaction partners for the bZIP proteins.
conclusionThis integration permits the bZIP dimerization network to be interpreted in functional terms, especially in the context of the role of bZIP proteins in the response to environmental stress. This analysis demonstrates the importance of abiotic factors in shaping regulatory networks.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.