ArticleLeukemia2006
MTB, the murine homolog of condensin II subunit CAP-G2, represses transcription and promotes erythroid cell differentiation.
Article in Leukemia, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 50 citations in OpenAlex.
- The Condensin II complex regulates essential gene expression programs during erythropoiesis.Development (Cambridge, England) · 2025Article
- SMC2 and Condensin II Subunits Are Essential for the Development of Hematopoietic Stem and Progenitor Cells in Zebrafish.Journal of cellular physiology · 2025Article
- Condensin I folds the Caenorhabditis elegans genome.Nature genetics · 2024Article
- Erythrocytes 3D genome organization in vertebrates.Scientific reports · 2021Article
- Condensin I is required for faithful meiosis in Drosophila males.Chromosoma · 2020Article
- Article
- Cellular dynamics of mammalian red blood cell production in the erythroblastic island niche.Biophysical reviews · 2019Review
- Plant condensin II is required for the correct spatial relationship between centromeres and rDNA arrays.Nucleus (Austin, Tex.) · 2019Article
- Condensin II protein dysfunction impacts mitochondrial respiration and mitochondrial oxidative stress responses.Journal of cell science · 2019Article
- Comparing and Contrasting the Effects ofGenetics · 2018Article
- The loading of condensin in the context of chromatin.Current genetics · 2017Review
- Drosophila Condensin II subunit Chromosome-associated protein D3 regulates cell fate determination through non-cell-autonomous signaling.Development (Cambridge, England) · 2016Article
- Nuclear Condensation during Mouse Erythropoiesis Requires Caspase-3-Mediated Nuclear Opening.Developmental cell · 2016Article
- Condensin II Regulates Interphase Chromatin Organization Through the Mrg-Binding Motif of Cap-H2.G3 (Bethesda, Md.) · 2015Article
- A Chemical Screening Approach to Identify Novel Key Mediators of Erythroid Enucleation.PloS one · 2015Article
- Inactivation of SMC2 shows a synergistic lethal response in MYCN-amplified neuroblastoma cells.Cell cycle (Georgetown, Tex.) · 2014Article
- Condensin-mediated chromosome organization and gene regulation.Frontiers in genetics · 2014Review
- Condensins and 3D Organization of the Interphase Nucleus.Current genetic medicine reports · 2013Article
- Condensin II subunit dCAP-D3 restricts retrotransposon mobilization in Drosophila somatic cells.PLoS genetics · 2013Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Chromosome condensation is essential for proper segregation of duplicated sister chromatids in mitosis. Mammalian erythroid maturation is also associated with gradual nuclear condensation. However, few proteins that are directly involved in chromosome condensation during erythropoiesis have been identified. In this report, we show that MTB (more than blood), which was initially isolated in a yeast two-hybrid screen for proteins that interact with the basic helix-loop-helix (bHLH) protein stem cell leukemia (SCL), and later identified as the murine homolog of the condensin II subunit CAP-G2, participates in erythroid cell development. MTB interacts with SCL and another hematopoietic bHLH protein, E12, and is recruited to the nucleus by SCL and E12. In addition, MTB can repress SCL/E12-mediated transcriptional activation. Consistent with the model that MTB may function together with SCL/E12 heterodimer during erythroid cell development, MTB is highly expressed in the erythroid lineage and is upregulated upon erythroid differentiation. Moreover, overexpression of MTB promotes the terminal differentiation of the murine erythroleukemia erythroid cell line. Together, these findings demonstrate that the condensin II subunit MTB/mCAP-G2 plays a novel function during erythropoiesis and suggest that key hematopoietic transcription factors such as SCL and E12 may regulate the terminal differentiation of hematopoietic cells through the interaction with condensin complexes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.