ArticleBritish journal of pharmacology1991
Ca2+ channel activation and membrane depolarization mediated by Cl- channels in response to noradrenaline in vascular myocytes.
Article in British journal of pharmacology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 88 citations in OpenAlex.
- Arteriolar oxygen reactivity: where is the sensor and what is the mechanism of action?The Journal of physiology · 2016Review
- Molecular and functional significance of Ca(2+)-activated Cl(-) channels in pulmonary arterial smooth muscle.Pulmonary circulation · 2015Review
- TMEM16A knockdown abrogates two different Ca(2+)-activated Cl (-) currents and contractility of smooth muscle in rat mesenteric small arteries.Pflugers Archiv : European journal of physiology · 2014Article
- The role of K+ and Cl- channels in the regulation of retinal arteriolar tone and blood flow.Investigative ophthalmology & visual science · 2014Article
- Contribution of Ca²⁺-dependent Cl⁻ channels to norepinephrine-induced contraction of femoral artery is replaced by increasing EDCF contribution during ageing.BioMed research international · 2014Article
- Regulation of cerebral artery smooth muscle membrane potential by Ca²⁺-activated cation channels.Microcirculation (New York, N.Y. : 1994) · 2013Review
- Article
- Size-dependent heterogeneity of contractile Ca2+ sensitization in rat arterial smooth muscle.The Journal of physiology · 2012Article
- Ca2+-activated Cl- current in retinal arteriolar smooth muscle.Investigative ophthalmology & visual science · 2009Article
- Effects of calcium channel blockers on antidepressant action of Alprazolam and Imipramine.The Libyan journal of medicine · 2007Article
- Sympathetic neural inhibition of conducted vasodilatation along hamster feed arteries: complementary effects of alpha1- and alpha2-adrenoreceptor activation.The Journal of physiology · 2005Article
- Electrophysiological characterization and functional importance of calcium-activated chloride channel in rat uterine myocytes.Pflugers Archiv : European journal of physiology · 2004Article
- Measurement of chloride flux associated with the myogenic response in rat cerebral arteries.The Journal of physiology · 2001Article
- Alteration of the [Ca(2+)](i)-force relationship during the vasorelaxation induced by a Ca(2+) channel blocker SR33805 in the porcine coronary artery.British journal of pharmacology · 2000Article
- Vasorelaxation and inhibition of the voltage-operated Ca2+ channels by FK506 in the porcine coronary artery.British journal of pharmacology · 1999Article
- Non-specificity of chloride channel blockers in rat cerebral arteries: block of the L-type calcium channel.The Journal of physiology · 1998Article
- Chloride channel blockers inhibit myogenic tone in rat cerebral arteries.The Journal of physiology · 1997Article
- Functional evidence of inverse agonism in vascular smooth muscle.British journal of pharmacology · 1996Article
- Characterization of the P2Y-purinoceptor involved in the ATP-induced rise in cytosolic Ca2+ concentration in rat ileal myocytes.British journal of pharmacology · 1996Article
- Rise in cytosolic Ca2+ concentration induced by P2-purinoceptor activation in isolated myocytes from the rat gastrointestinal tract.British journal of pharmacology · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The effects of noradrenaline (NA) were studied on vascular smooth muscle cells isolated from rat portal vein. 2. Two types of single-Ca2+ channel currents with conductances of 17 pS and 8 pS were obtained in cell-attached configuration. Bath application of NA increased the open probability of both channels during depolarizing pulses without a change of background membrane conductance. However, NA did not open Ca2+ channels when the membrane patch potential was held at -50 mV, which is about the resting potential in physiological conditions. 3. In the whole-cell configuration, studies of voltage-dependent Ca2+ channel currents showed that the peak conductance curve was not shifted to more negative potentials by NA. 4. Measurements of internal Ca(2+)-concentration ([Ca2+]i) with Indo-1 indicated that NA increased [Ca2+]i at a holding potential of -50 mV and evoked a Ca(2+)-activated Cl- current. These effects were blocked when heparin was included in the pipette solution. 5. A Cl- channel blocker without effect on Ca2+ channels (anthracene-9-carboxylic acid) inhibited the contractions of portal vein strips induced by NA in a manner similar to that produced by a Ca2+ channel inhibitor (isradipine). The NA-induced contraction was completely suppressed in the presence of ryanodine which depletes intracellular Ca2+ stores. 6. The present study suggests that activation of Cl- channels by Ca2+ release produces a membrane depolarization which is a prerequisite for enhanced opening of voltage-dependent Ca2+ channels in response to NA in venous smooth muscle.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.