ArticleJournal of bacteriology2006
Ecf, an alternative sigma factor from Neisseria gonorrhoeae, controls expression of msrAB, which encodes methionine sulfoxide reductase.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Where metabolism and virulence meet-sulfoxide reductases as determinants of bacterial survival.Biochemical Society transactions · 2026Review
- Flavin affinity for the reductase HpaC differentially sensitizes Neisseria gonorrhoeae during Type IV pilus-dependent killing.PLoS pathogens · 2025Article
- Dual species transcriptomics reveals conserved metabolic and immunologic processes in interactions between human neutrophils and Neisseria gonorrhoeae.PLoS pathogens · 2024Article
- Bacterial Stress Responses as Potential Targets in Overcoming Antibiotic Resistance.Microorganisms · 2022Review
- The Alternative Sigma Factor RpoE2 Is Involved in the Stress Response to Hypochlorite andFrontiers in microbiology · 2021Article
- TheFrontiers in immunology · 2019Article
- Neisseria gonorrhoeae host adaptation and pathogenesis.Nature reviews. Microbiology · 2018Review
- Transcriptomic buffering of cryptic genetic variation contributes to meningococcal virulence.BMC genomics · 2017Article
- Impact of Moderate Temperature Changes on Neisseria meningitidis Adhesion Phenotypes and Proteome.Infection and immunity · 2016Article
- Correia Repeat Enclosed Elements and Non-Coding RNAs in the Neisseria Species.Microorganisms · 2016Article
- Transcriptional landscape and essential genes of Neisseria gonorrhoeae.Nucleic acids research · 2014Article
- Identification of sRNAs expressed by the human pathogen Neisseria gonorrhoeae under disparate growth conditions.Frontiers in microbiology · 2014Article
- Extracytoplasmic function (ECF) sigma factor σF is involved in Caulobacter crescentus response to heavy metal stress.BMC microbiology · 2012Article
- The extracytoplasmic function sigma factor σS protects against both intracellular and extracytoplasmic stresses in Staphylococcus aureus.Journal of bacteriology · 2012Article
- Protocol for gene expression profiling using DNA microarrays in Neisseria gonorrhoeae.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Article
- A comparison of the endotoxin biosynthesis and protein oxidation pathways in the biogenesis of the outer membrane of Escherichia coli and Neisseria meningitidis.Frontiers in cellular and infection microbiology · 2012Review
- Deep sequencing whole transcriptome exploration of the σE regulon in Neisseria meningitidis.PloS one · 2011Article
- The structure of the first representative of Pfam family PF09836 reveals a two-domain organization and suggests involvement in transcriptional regulation.Acta crystallographica. Section F, Structural biology and crystallization communications · 2010Article
- Identification of a novel anti-sigmaE factor in Neisseria meningitidis.BMC microbiology · 2010Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
A DNA microarray was used to identify genes transcribed in Neisseria gonorrhoeae using Ecf, an alternative sigma factor. No differences between the transcriptional profiles of strain FA1090 and a mutant where ecf had been inactivated could be detected when both were grown in vitro. We therefore constructed a gonococcal strain in which Ecf can be overexpressed. Some differentially expressed genes are clustered with ecf on the genome and appear to form a single transcriptional unit. Expression of the gene encoding MsrAB, which possesses methionine sulfoxide reductase activity, was also dependent on Ecf, suggesting that the regulon responds to oxidative damage. Western blotting confirmed that the increased level of MsrAB protein is dependent on the presence of Ecf.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.