ArticleApplied and environmental microbiology2006
Effects of various growth conditions in a chemostat on expression of virulence factors in Porphyromonas gingivalis.
Article in Applied and environmental microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Inhibitory Effects of the Heat-Killed Lactic Acid BacteriumCurrent therapeutic research, clinical and experimental · 2024Article
- Prevalence and Phylogenetic Analysis of Lipoprotein-GeneAntibiotics (Basel, Switzerland) · 2023Article
- The RagA and RagB proteins of Porphyromonas gingivalis.Molecular oral microbiology · 2021Review
- Antibacterial activity of plant species used for oral health against Porphyromonas gingivalis.PloS one · 2020Article
- Identification of OmpA-Like Protein of Tannerella forsythia as an O-Linked Glycoprotein and Its Binding Capability to Lectins.PloS one · 2016Article
- Characterization of wheat germ agglutinin lectin-reactive glycosylated OmpA-like proteins derived from Porphyromonas gingivalis.Infection and immunity · 2014Article
- Porphyromonas gingivalis: keeping the pathos out of the biont.Journal of oral microbiology · 2013Article
- Article
- The native 67-kilodalton minor fimbria of Porphyromonas gingivalis is a novel glycoprotein with DC-SIGN-targeting motifs.Journal of bacteriology · 2010Article
- Tetratricopeptide repeat protein-associated proteins contribute to the virulence of Porphyromonas gingivalis.Infection and immunity · 2010Article
- Histidine kinase-mediated production and autoassembly of Porphyromonas gingivalis fimbriae.Journal of bacteriology · 2010Article
- Anchoring and length regulation of Porphyromonas gingivalis Mfa1 fimbriae by the downstream gene product Mfa2.Microbiology (Reading, England) · 2009Article
- Identification of a gingipain-sensitive surface ligand of Porphyromonas gingivalis that induces Toll-like receptor 2- and 4-independent NF-kappaB activation in CHO cells.Infection and immunity · 2009Article
- Porphyromonas gingivalis short fimbriae are regulated by a FimS/FimR two-component system.FEMS microbiology letters · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Porphyromonas gingivalis, one of the gram-negative organisms associated with periodontal disease, possesses potential virulence factors, including fimbriae, proteases, and major outer membrane proteins (OMPs). In this study, P. gingivalis ATCC 33277 was cultured in a chemostat under hemin excess and presumably peptide-limiting conditions to better understand the mechanisms of expression of the virulence factors upon environmental changes. At higher growth rates, the amounts of FimA and the 75-kDa protein, forming long and short fimbriae, respectively, increased significantly, whereas gingipains decreased in amount and activity. In a nutrient-limited medium, lesser amounts of the above two fimbrial proteins were observed, whereas clear differences were not found in the amounts of gingipains. In addition, two-dimensional electrophoresis revealed that proteins in cells were generally fewer in number during nutrient-limited growth. Under aeration, a considerable reduction in gingipain activity was found, whereas several proteins associated with intact cells significantly increased. However, the expression of major OMPs, such as RagA, RagB, and the OmpA-like proteins, was almost constant under all conditions tested. These results suggest that P. gingivalis may actively control expression of several virulence factors to survive in the widely fluctuating oral environment.
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