ArticleApplied and environmental microbiology2006
Characterization of novel carbazole catabolism genes from gram-positive carbazole degrader Nocardioides aromaticivorans IC177.
Article in Applied and environmental microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 59 citations in OpenAlex.
- The potential application of carbazole-degrading bacteria for dioxin bioremediation.Bioresources and bioprocessing · 2023Review
- Analysis of a novel strain Brevundimonas KX-1 capable of degrading 3-chlorocarbazole based on the whole genome sequence.Antonie van Leeuwenhoek · 2023Article
- Crystal structure of the ferredoxin reductase component of carbazole 1,9a-dioxygenase from Janthinobacterium sp. J3.Acta crystallographica. Section D, Structural biology · 2021Article
- Nocardioides antri sp. nov., Isolated from Soil in a Rock Cave.Current microbiology · 2021Article
- Multiple Gene Clusters and Their Role in the Degradation of Chlorophenoxyacetic Acids in Bradyrhizobium sp. RD5-C2 Isolated from Non-Contaminated Soil.Microbes and environments · 2021Article
- Dissipation, dehalogenation, and denitration of chloroaromatic compounds byJournal of pesticide science · 2019Article
- Properties, environmental fate and biodegradation of carbazole.3 Biotech · 2017Review
- Structural basis of the divergent oxygenation reactions catalyzed by the rieske nonheme iron oxygenase carbazole 1,9a-dioxygenase.Applied and environmental microbiology · 2014Article
- Isolation and characterization of a new Achromobacter sp. strain CAR1389 as a carbazole-degrading bacterium.World journal of microbiology & biotechnology · 2012Article
- Phylogenetic framework and molecular signatures for the main clades of the phylum Actinobacteria.Microbiology and molecular biology reviews : MMBR · 2012Review
- Nocardioides sp. strain WSN05-2, isolated from a wheat field, degrades deoxynivalenol, producing the novel intermediate 3-epi-deoxynivalenol.Applied microbiology and biotechnology · 2011Article
- Cloning and nucleotide sequences of carbazole degradation genes from marine bacterium Neptuniibacter sp. strain CAR-SF.Current microbiology · 2010Article
- Isolation and characterization of a car gene cluster from the naphthalene, phenanthrene, and carbazole-degrading marine isolate Lysobacter sp. strain OC7.Current microbiology · 2009Article
- Pathway and evolutionary implications of diphenylamine biodegradation by Burkholderia sp. strain JS667.Applied and environmental microbiology · 2009Article
- Bacterial degradation of aromatic compounds.International journal of environmental research and public health · 2009Review
- Crystallization and preliminary crystallographic analysis of the ferredoxin component of carbazole 1,9a-dioxygenase from Nocardioides aromaticivorans IC177.Acta crystallographica. Section F, Structural biology and crystallization communications · 2007Article
- Crystallization and preliminary X-ray diffraction studies of the ferredoxin reductase component in the Rieske nonhaem iron oxygenase system carbazole 1,9a-dioxygenase.Acta crystallographica. Section F, Structural biology and crystallization communications · 2007Article
- Crystallization and preliminary X-ray diffraction studies of the terminal oxygenase component of carbazole 1,9a-dioxygenase from Nocardioides aromaticivorans IC177.Acta crystallographica. Section F, Structural biology and crystallization communications · 2006Article
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4 authors at 1 institution in 1 country.
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Abstract
Nocardioides aromaticivorans IC177 is a gram-positive carbazole degrader. The genes encoding carbazole degradation (car genes) were cloned into a cosmid clone and sequenced partially to reveal 19 open reading frames. The car genes were clustered into the carAaCBaBbAcAd and carDFE gene clusters, encoding the enzymes responsible for the degradation of carbazole to anthranilate and 2-hydroxypenta-2,4-dienoate and of 2-hydroxypenta-2,4-dienoate to pyruvic acid and acetyl coenzyme A, respectively. The conserved amino acid motifs proposed to bind the Rieske-type [2Fe-2S] cluster and mononuclear iron, the Rieske-type [2Fe-2S] cluster, and flavin adenine dinucleotide were found in the deduced amino acid sequences of carAa, carAc, and carAd, respectively, which showed similarities with CarAa from Sphingomonas sp. strain KA1 (49% identity), CarAc from Pseudomonas resinovorans CA10 (31% identity), and AhdA4 from Sphingomonas sp. strain P2 (37% identity), respectively. Escherichia coli cells expressing CarAaAcAd exhibited major carbazole 1,9a-dioxygenase (CARDO) activity. These data showed that the IC177 CARDO is classified into class IIB, while gram-negative CARDOs are classified into class III or IIA, indicating that the respective CARDOs have diverse types of electron transfer components and high similarities of the terminal oxygenase. Reverse transcription-PCR (RT-PCR) experiments showed that the carAaCBaBbAcAd and carDFE gene clusters are operonic. The results of quantitative RT-PCR experiments indicated that transcription of both operons is induced by carbazole or its metabolite, whereas anthranilate is not an inducer. Biotransformation analysis showed that the IC177 CARDO exhibits significant activities for naphthalene, carbazole, and dibenzo-p-dioxin but less activity for dibenzofuran and biphenyl.
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