ArticleApplied and environmental microbiology2006
Isolation and characterization of acid-tolerant, thermophilic bacteria for effective fermentation of biomass-derived sugars to lactic acid.
Article in Applied and environmental microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed.
- Molecular identification and hydrolase activity profiling of bacteria isolated from septic surface environments using 16S rRNA sequencing.Molecular biology reports · 2026Article
- Carbohydrate concentration and type drive product selectivity to a mixture of volatile fatty acids or lactic acid in thermophilic mixed-culture fermentation.Applied microbiology and biotechnology · 2026Article
- Assessing the Probiotic Properties and safety of Limosilactobacillus reuteri LP4 Isolated from Apis cerana Based on Whole Genome and Phenotype Analyses.Probiotics and antimicrobial proteins · 2026Article
- Nutrient-free biorefinery of corn steep water into lactic acid by Bacillus licheniformis OP16-2 under thermo-alkaline conditions with a pilot-scale assessment.Scientific reports · 2026Article
- Advances in L-Lactic Acid Production from Lignocellulose Using Genetically Modified Microbial Systems.Polymers · 2025Review
- Expanded genome and proteome reallocation in a novel, robustmSystems · 2024Article
- Sauerkraut-derived LAB strains as potential probiotic candidates for modulating carbohydrate digestion attributing bacterial organic acid profiling to antidiabetic activity.Food science & nutrition · 2024Article
- Global trends and future prospects of lactic acid production from lignocellulosic biomass.RSC advances · 2023Article
- Differential Immune-Modulating Activities of Cell Walls and Secreted Metabolites from ProbioticMicroorganisms · 2023Article
- Prediction and validation of novel SigB regulon members in Bacillus subtilis and regulon structure comparison to Bacillales members.BMC microbiology · 2023Article
- Identification and functional analysis of novel protein-encoding sequences related to stress-resistance.Frontiers in microbiology · 2023Article
- Effective gossypol removal from cottonseed meal through optimized solid-state fermentation by Bacillus coagulans.Microbial cell factories · 2022Article
- Simultaneous saccharification and lactic acid fermentation of the cellulosic fraction of municipal solid waste using Bacillus smithii.Biotechnology letters · 2021Article
- Kinetic characterization and structure analysis of an altered polyol dehydrogenase with d-lactate dehydrogenase activity.Protein science : a publication of the Protein Society · 2020Article
- Lactic acid production - producing microorganisms and substrates sources-state of art.Heliyon · 2020Review
- Microbial response to acid stress: mechanisms and applications.Applied microbiology and biotechnology · 2020Review
- Effects of Soaking and Fermentation Time on Biogenic Amines Content ofFoods (Basel, Switzerland) · 2019Article
- Metabolic engineering ofBiotechnology for biofuels · 2019Article
- Co-fermentation of the main sugar types from a beechwood organosolv hydrolysate by several strains ofBiotechnology reports (Amsterdam, Netherlands) · 2018Article
- Genetic Tools and Techniques for Recombinant Expression in Thermophilic Bacillaceae.Microorganisms · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biomass-derived sugars, such as glucose, xylose, and other minor sugars, can be readily fermented to fuel ethanol and commodity chemicals by the appropriate microbes. Due to the differences in the optimum conditions for the activity of the fungal cellulases that are required for depolymerization of cellulose to fermentable sugars and the growth and fermentation characteristics of the current industrial microbes, simultaneous saccharification and fermentation (SSF) of cellulose is envisioned at conditions that are not optimal for the fungal cellulase activity, leading to a higher-than-required cost of cellulase in SSF. We have isolated bacterial strains that grew and fermented both glucose and xylose, major components of cellulose and hemicellulose, respectively, to l(+)-lactic acid at 50 degrees C and pH 5.0, conditions that are also optimal for fungal cellulase activity. Xylose was metabolized by these new isolates through the pentose-phosphate pathway. As expected for the metabolism of xylose by the pentose-phosphate pathway, [(13)C]lactate accounted for more than 90% of the total (13)C-labeled products from [(13)C]xylose. Based on fatty acid profile and 16S rRNA sequence, these isolates cluster with Bacillus coagulans, although the B. coagulans type strain, ATCC 7050, failed to utilize xylose as a carbon source. These new B. coagulans isolates have the potential to reduce the cost of SSF by minimizing the amount of fungal cellulases, a significant cost component in the use of biomass as a renewable resource, for the production of fuels and chemicals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.