Evidence map›Paper›PMID 16672418›Full record

ArticleJournal of clinical microbiology2006

Cytolethal distending toxin in Escherichia coli O157:H7: spectrum of conservation, structure, and endothelial toxicity.

Alexander W Friedrich, Shan Lu, Martina Bielaszewska, Rita Prager, Phillip Bruns, Jian-Guo Xu, Helmut Tschäpe, Helge Karch

Open access · greenAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 53 citations in OpenAlex.

  1. EnterohemorrhagicFrontiers in cellular and infection microbiology · 2025
    Article
  2. Article
  3. LRRC8A promotesVirulence · 2023
    Article
  4. Article
  5. Article
  6. EnterohemorrhagicInternational journal of molecular sciences · 2022
    Review
  7. Article
  8. Review
  9. Virulence factors of Shiga toxin-producing Escherichia coli and the risk of developing haemolytic uraemic syndrome in Norway, 1992-2013.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017
    Article
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  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Alexander W FriedrichInstitute for Hygiene, the National Consulting Laboratory on Hemolytic Uremic Syndrome, University Hospital Münster, Robert Koch Str. 41, and the IZKF Münster, 48149 Münster, Germany.
Shan Lu
Martina Bielaszewska
Rita Prager
Phillip Bruns
Jian-Guo Xu
Helmut Tschäpe
Helge Karch
University Hospital Münster · DEChinese Center For Disease Control and Prevention · CNRobert Koch Institute · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We identified the cytolethal distending toxin V (CDT-V) gene cluster in 19 (4.9%) of 391 enterohemorrhagic Escherichia coli O157:H7. cdt-V+ strains belonged to five phage types (PTs) and were most frequent within PTs 14 and 34. CDT-V was expressed in all but two cdt-V+ strains and was lethal to cultured endothelial cells. Subtyping schemes should include cdt-V as a marker to differentiate E. coli O157:H7 even within the same phage type.

Indexed as

AllelesBacterial ToxinsBase SequenceCell LineConserved SequenceDiarrheaDNA, BacterialEndothelium, VascularEscherichia coli InfectionsEscherichia coli O157Evolution, MolecularGenes, BacterialHemolytic-Uremic SyndromeHumansMultigene FamilyVirulenceBacterial Toxinscytolethal distending toxinDNA, Bacterial

Identifiers

PMID16672418
PMCPMC1479162
OpenAlexW2111959427

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.