ArticleJournal of clinical microbiology2006
Longitudinal farm study of extended-spectrum beta-lactamase-mediated resistance.
Article in Journal of clinical microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 122 citations in OpenAlex.
- Whole-genome sequencing-based antimicrobial resistance and shedding dynamics ofMicrobiology spectrum · 2024Article
- Invited Review: Antimicrobial Use and Antimicrobial Resistance in Pathogens Associated with Diarrhea and Pneumonia in Dairy Calves.Animals : an open access journal from MDPI · 2022Review
- Role played by the environment in the emergence and spread of antimicrobial resistance (AMR) through the food chain.EFSA journal. European Food Safety Authority · 2021Article
- Plasmid- and strain-specific factors drive variation in ESBL-plasmid spread in vitro and in vivo.The ISME journal · 2021Article
- Ceftiofur reduced Fusobacterium leading to uterine microbiota alteration in dairy cows with metritis.Animal microbiome · 2021Article
- Surveillance of Extended-Spectrum β-Lactamase-, Cephalosporinase- and Carbapenemase-Producing Gram-Negative Bacteria in Raw Milk Filters and Healthy Dairy Cattle in Three Farms inFrontiers in veterinary science · 2021Article
- Extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae in cattle production - a threat around the world.Heliyon · 2020Review
- Dynamics of faecal shedding of ESBL- or AmpC-producing Escherichia coli on dairy farms.The Journal of antimicrobial chemotherapy · 2019Article
- Prevalence of faecal carriage of extended-spectrum β-lactamase (ESBL)-producingVeterinary record open · 2019Article
- Molecular Epidemiology of Dairy Cattle-Associated Escherichia coli CarryingApplied and environmental microbiology · 2018Article
- Genomic and Virulence Characterization of Intrauterine PathogenicFrontiers in microbiology · 2018Article
- Mechanisms of quinolone resistance inJournal of veterinary science · 2017Article
- Nosocomial Intravascular Catheter Infections with Extended-spectrum Beta-lactamase-producing Escherichia coli in Calves after Strain Introduction from a Commercial Herd.Transboundary and emerging diseases · 2017Article
- Quantitative evaluation of extended-spectrum β-lactamase-producing Escherichia coli strains in the wastewater of a French teaching hospital and relation to patient strain.Antimicrobial resistance and infection control · 2016Article
- Eradication of methicillin-resistant Staphylococcus aureus and of Enterobacteriaceae expressing extended-spectrum beta-lactamases on a model pig farm.Applied and environmental microbiology · 2015Article
- Strain diversity of CTX-M-producing Enterobacteriaceae in individual pigs: insights into the dynamics of shedding during the production cycle.Applied and environmental microbiology · 2014Article
- Functional genomics to identify the factors contributing to successful persistence and global spread of an antibiotic resistance plasmid.BMC microbiology · 2014Article
- Article
- Prevalence of extended-spectrum β-lactamase-producing Escherichia coli on Bavarian dairy and beef cattle farms.Applied and environmental microbiology · 2013Article
- Cefotaxime resistant Escherichia coli collected from a healthy volunteer; characterisation and the effect of plasmid loss.PloS one · 2013Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extended-spectrum beta-lactamase (ESBL)-mediated resistance is of considerable importance in human medicine. Recently, such enzymes have been reported in bacteria from animals. We describe a longitudinal study of a dairy farm suffering calf scour with high mortality rates. In November 2004, two Escherichia coli isolates with resistance to a wide range of beta-lactams (including amoxicillin-clavulanate and cefotaxime) were isolated from scouring calves. Testing by PCR and sequence analysis confirmed the isolates as being both bla(CTX-M14/17) and bla(TEM-35) ((IRT-4)) positive. They had indistinguishable plasmid and pulsed-field gel electrophoresis (PFGE) profiles. Transferability studies demonstrated that bla(CTX-M) was located on a conjugative 65-MDa IncK plasmid. Following a farm visit in December 2004, 31/48 calves and 2/60 cows were positive for E. coli with bla(CTX-M). Also, 5/48 calf and 28/60 cow samples yielded bla(CTX)- and bla(TEM)-negative E. coli isolates that were resistant to cefotaxime, and sequence analysis confirmed that these presented mutations in the promoter region of the chromosomal ampC gene. Fingerprinting showed 11 different PFGE types (seven in bla(CTX-M)-positive isolates). Six different PFGE clones conjugated the same bla(CTX-M)-positive IncK plasmid. One clone carried a different-sized, bla(CTX-M)-positive, transformable plasmid. This is the first report of bla(CTX-M) from livestock in the United Kingdom, and this report demonstrates the complexity of ESBL epidemiology. Results indicate that horizontal plasmid transfer between strains as well as horizontal gene transfer between plasmids have contributed to the spread of resistance. We have also shown that some clones can persist for months, suggesting that clonal spread also contributes to the perpetuation of resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.